SB 203186 hydrochloride

Modify Date: 2024-01-02 21:52:02

SB 203186 hydrochloride structure	Common Name	SB 203186 hydrochloride
	CAS Number	207572-69-8	Molecular Weight	308.803
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₆H₂₁ClN₂O₂	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of SB 203186 hydrochloride

SB-203186 hydrochloride is a potent and competitive 5-HT4 antagonist. SB-203186 hydrochloride antagonizes the 5-HT4 receptor-mediated relaxations of the carbachol-contracted rat isolated oesophagus against 5-HT with pKB values of 10.9 (rat oesophagus), 9.5 (guinea-pig ileum), and 9.0 (human colon) respectively[1][2][3].

Name	2-(1-Piperidinyl)ethyl 1H-indole-3-carboxylate hydrochloride (1:1)
Synonym	More Synonyms

Description	SB-203186 hydrochloride is a potent and competitive 5-HT4 antagonist. SB-203186 hydrochloride antagonizes the 5-HT4 receptor-mediated relaxations of the carbachol-contracted rat isolated oesophagus against 5-HT with pKB values of 10.9 (rat oesophagus), 9.5 (guinea-pig ileum), and 9.0 (human colon) respectively[1][2][3].
Related Catalog	Research Areas >> Cardiovascular Disease Research Areas >> Neurological Disease Signaling Pathways >> GPCR/G Protein >> 5-HT Receptor Signaling Pathways >> Neuronal Signaling >> 5-HT Receptor
Target	pKB: 10.9 (5-HT4 in rat oesophagus), 9.5 (5-HT4 in guinea-pig ileum), and 9.0 (5-HT4 in human colon)[3].
In Vitro	SB-203186 (0.1-3mg/kg, i.v.) surmountably antagonised 5-HT-evoked tachycardia in anaesthetized Yucatan minipigs or new-born Camborough piglets with similar potency[1]. Pretreatment with SB-203186 (10 μM) enhances the 5-HT-induced contractions of the antral strips[2].
In Vivo	Intraduodenally administered SB-203186 (0.3-3 mg/kg) to new-born Camborough piglets produced blockade of 5-HT-evoked tachycardia which was maximal after 20 min and lasted for more than 3 h with 0.3 mg/kg[1].
References	[1]. S G Parker, et al. Blockade of human and porcine myocardial 5-HT4 receptors by SB 203186. Naunyn Schmiedebergs Arch Pharmacol. 1995 Dec;353(1):28-35. [2]. Tohru Komada, et al. Pharmacological characterization of 5-Hydroxytryptamine-receptor subtypes in circular muscle from the rat stomach. Biol Pharm Bull. 2007 Mar;30(3):508-13. [3]. P G McLean, et al. 5-HT4 receptor antagonist affinities of SB207710, SB205008, and SB203186 in the human colon, rat oesophagus, and guinea-pig ileum peristaltic reflex. Naunyn Schmiedebergs Arch Pharmacol. 1995 Aug;352(2):132-40.

Molecular Formula	C₁₆H₂₁ClN₂O₂
Molecular Weight	308.803
Exact Mass	308.129150

Hazard Codes	Xi
Risk Phrases	36/37/38
Safety Phrases	26-36

2-(Piperidin-1-yl)ethyl 1H-indole-3-carboxylate hydrochloride (1:1)

2-(1-Piperidinyl)ethyl 1H-indole-3-carboxylate hydrochloride (1:1)

1H-Indole-3-carboxylic acid, 2-(1-piperidinyl)ethyl ester, hydrochloride (1:1)

SB-203186 hydrochloride

DC Chemicals Limited
China
Product Name: SB-203186 hydrochloride
Price: $Inquiry/250mg $Inquiry/100mg $Inquiry/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 1-Piperidinylethyl-1H-indole-3-carboxylate hydrochloride
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

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