PF-06726304 acetate
Modify Date: 2024-01-09 23:56:47
PF-06726304 acetate structure
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Common Name | PF-06726304 acetate | ||
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| CAS Number | 2080306-28-9 | Molecular Weight | 506.38 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C24H25Cl2N3O5 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of PF-06726304 acetatePF-06726304 acetate is a potent and selective EZH2 inhibitor. PF-06726304 acetate inhibits wild-type and Y641N mutant EZH2 with Kis of 0.7 and 3.0 nM, respectively. PF-06726304 acetate displays robust antitumor growth activity[1]. |
| Name | PF-06726304 acetate |
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| Description | PF-06726304 acetate is a potent and selective EZH2 inhibitor. PF-06726304 acetate inhibits wild-type and Y641N mutant EZH2 with Kis of 0.7 and 3.0 nM, respectively. PF-06726304 acetate displays robust antitumor growth activity[1]. |
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| Related Catalog | |
| Target |
EZH2 WT:0.7 nM (Ki) EZH2 Y641N:3.0 nM (Ki) |
| In Vitro | PF-06726304 (Compound 31) inhibits H3K27me3 in Karpas-422 with an IC50 of 15 nM[1]. PF-06726304 inhibits the proliferation of Karpas-422 cells that harbor wild-type EZH2 with an IC50 of 25 nM[1]. |
| In Vivo | PF-06726304 (200 and 300 mg/kg; BID for 20 days) inhibits tumor growth and induces robust modulation of downstream biomarkers in a subcutaneous Karpas-422 xenograft model[1]. Animal Model: Female Scid beige mice (6-8 weeks old) with Karpas-422 xenograft model[1] Dosage: 200 and 300 mg/kg Administration: Given BID for 20 days Result: Inhibited tumor growth and induced robust modulation of downstream biomarkers in a subcutaneous Karpas-422 xenograft model. |
| References |
| Molecular Formula | C24H25Cl2N3O5 |
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| Molecular Weight | 506.38 |