Okadaic acid sodium
Modify Date: 2024-01-09 11:47:49
Okadaic acid sodium structure
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Common Name | Okadaic acid sodium | ||
|---|---|---|---|---|
| CAS Number | 209266-80-8 | Molecular Weight | 826.985 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C44H67NaO13 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | N/A | |
| Symbol |
GHS06 |
Signal Word | Danger | |
Use of Okadaic acid sodiumOkadaic acid sodium, a marine toxin, is an inhibitor of protein phosphatases (PP). Okadaic acid (sodium) has a significantly higher affinity for PP2A (IC50=0.1-0.3 nM), and inhibits PP1 (IC50=15-50 nM), PP3 (IC50=3.7-4 nM), PP4 (IC50=0.1 nM), PP5 (IC50=3.5 nM), but does not inhibit PP2C. Okadaic acid sodium increases of phosphorylation of a number of proteins by inhibiting PP, and acts a tumor promoter. Okadaic acid sodium induces tau phosphorylation[1][2]. |
| Name | okadaic acid sodium salt |
|---|---|
| Synonym | More Synonyms |
| Description | Okadaic acid sodium, a marine toxin, is an inhibitor of protein phosphatases (PP). Okadaic acid (sodium) has a significantly higher affinity for PP2A (IC50=0.1-0.3 nM), and inhibits PP1 (IC50=15-50 nM), PP3 (IC50=3.7-4 nM), PP4 (IC50=0.1 nM), PP5 (IC50=3.5 nM), but does not inhibit PP2C. Okadaic acid sodium increases of phosphorylation of a number of proteins by inhibiting PP, and acts a tumor promoter. Okadaic acid sodium induces tau phosphorylation[1][2]. |
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| Related Catalog | |
| Target |
PP1:15-50 nM (IC50) PP2A:0.1-0.3 nM (IC50) PP3:3.7-4 nM (IC50) PP4:0.1 nM (IC50) PP5:3.5 nM (IC50) PP2B:~4000 nM (IC50) PP7:>1000 nM (IC50) |
| In Vitro | Okadaic acid sodium (0-100 nM；24 小时或 48 小时) 抑制 AGS、MNK-45、Caco 2 细胞的增殖[3]。 Okadaic acid sodium (10 nM；8 小时) 增加大鼠皮层神经元中的 Drp1 磷酸化和线粒体裂变[4]。 Cell Proliferation Assay[3] Cell Line: AGS, MNK-45 and Caco 2 cell lines Concentration: 0-100 nM Incubation Time: 24 h or 48 h Result: Inhibited the proliferation of AGS, MNK-45, Caco 2 cells. |
| In Vivo | Okadaic acid sodium (100 μM；单侧注射到外侧杏仁核) 在注射后 24 小时，诱导解剖学上不同大脑区域的 Tau 磷酸化和蛋白质聚集[5]。 |
| References |
| Molecular Formula | C44H67NaO13 |
|---|---|
| Molecular Weight | 826.985 |
| Exact Mass | 826.447937 |
| PSA | 185.66000 |
| LogP | 3.87890 |
| Storage condition | 20°C |
| Symbol |
GHS06 |
|---|---|
| Signal Word | Danger |
| Hazard Statements | H301 + H311 + H331-H315 |
| Precautionary Statements | Missing Phrase - N15.00950417-P261-P280-P302 + P352 + P312-P304 + P340 + P312-P403 + P233 |
| Hazard Codes | T |
| Risk Phrases | R23/24/25;R38 |
| Safety Phrases | S28-S36/37/39-S38-S45 |
| RIDADR | UN 3462 6.1/PG 1 |
| 1,7-Dioxaspiro[5.5]undec-10-ene-2-propanoic acid, α,5-dihydroxy-α,10-dimethyl-8-[(1R,2E)-1-methyl-3-[(2R,4a'R,5R,6'S,8'R,8a'S)-octahydro-8'-hydroxy-6'-[(1S,3S)-1-hydroxy-3-[(2S,3R,6S)-3-methyl-1,7-dioxaspiro[5.5]undec-2-yl]butyl]-7'-methylenespiro[furan-2(3H),2'(3'H)-pyrano[3,2-b]pyran]-5-yl]-2-propen-1-yl]-, sodium salt, (αR,2S,5R,6R,8S)- (1:1) |
| Sodium (2R)-2-hydroxy-3-[(2S,5R,6R,8S)-5-hydroxy-8-{(2R,3E)-4-[(2R,4a'R,5R,6'S,8'R,8a'S)-8'-hydroxy-6'-{(1S,3S)-1-hydroxy-3-[(2S,3R,6S)-3-methyl-1,7-dioxaspiro[5.5]undec-2-yl]butyl}-7'-methyleneoctahydro-3H,3'H-spiro[furan-2,2'-pyrano[3,2-b]pyran]-5-yl]but-3-en-2-yl}-10-methyl-1,7-dioxaspiro[5.5]undec-10-en-2-yl]-2-methylpropanoate |
| Okadaic acid sodium salt (high purity) |
| Okadaic acid sodium salt,high purity |
| 9,10-DEEPITHIO-9,10-DIDEHYDROACANTHIOFOLICIN |
| HALOCHONDRINE A,SODIUM SALT |
| Sodium (2R)-2-hydroxy-3-[(2S,5R,6R,8S)-5-hydroxy-8-{(2R,3E)-4-[(2R,4a'R,5R,6'S,8'R,8a'S)-8'-hydroxy-6'-{(1S,3S)-1-hydroxy-3-[(2S,3R,6S)-3-methyl-1,7-dioxaspiro[5.5]undec-2-yl]butyl}-7'-methyleneoctahydro-3H,3'H-spiro[furan-2,2'-pyrano[3,2-b]pyran]-5-yl]-3-buten-2-yl}-10-methyl-1,7-dioxaspiro[5.5]undec-10-en-2-yl]-2-methylpropanoate |
| 9,10-DEEPITHIO-9,10-DIDEHYDROACANTHIFOLICIN SODIUM |
| 1,7-Dioxaspiro[5.5]undec-10-ene-2-propanoic acid, α,5-dihydroxy-α,10-dimethyl-8-[(1R,2E)-1-methyl-3-[(2R,4a'R,5R,6'S,8'R,8a'S)-octahydro-8'-hydroxy-6'-[(1S,3S)-1-hydroxy-3-[(2S,3R,6S)-3-methyl -1,7-dioxaspiro[5.5]undec-2-yl]butyl]-7'-methylenespiro[furan-2(3H),2'(3'H)-pyrano[3,2-b]pyran]-5-yl]-2-propen-1-yl]-, sodium salt, (αR,2S,5R,6R,8S)- (1:1) |
| OKADAIC ACID SODIUM |
| okadaic acid sodium salt from prorocentrum concavum |
| MFCD00210208 |