OTS186935

Modify Date: 2024-01-28 11:21:27

OTS186935 Structure
OTS186935 structure
Common Name OTS186935
CAS Number 2093400-18-9 Molecular Weight 463.96
Density N/A Boiling Point N/A
Molecular Formula C25H26ClN5O2 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of OTS186935


OTS186935 is a protein methyltransferase SUV39H2 inhibitor with an IC50 of 6.49 nM[1].

 Names

Name OTS186935

 OTS186935 Biological Activity

Description OTS186935 is a protein methyltransferase SUV39H2 inhibitor with an IC50 of 6.49 nM[1].
Related Catalog
Target

IC50: 6.49 nM (SUV39H2)[1]

In Vitro OTS186935 inhibits A549 cell growth with IC50 of 0.67 μM[1].
In Vivo OTS186935 reveales significant inhibition of tumor growth in mouse xenograft models using MDA-MB-231 breast cancer cells and A549 lung cancer cells without any detectable toxicity[1].
References

[1]. Vougiouklakis T, et al. Development of novel SUV39H2 inhibitors that exhibit growth suppressive effects in mouse xenograft models and regulate the phosphorylation of H2AX. Oncotarget. 2018 Aug 7;9(61):31820-31831.

 Chemical & Physical Properties

Molecular Formula C25H26ClN5O2
Molecular Weight 463.96