T-1095
Modify Date: 2024-01-08 22:43:08
T-1095 structure
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Common Name | T-1095 | ||
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| CAS Number | 209746-59-8 | Molecular Weight | 516.49 | |
| Density | 1.4±0.1 g/cm3 | Boiling Point | 732.3±60.0 °C at 760 mmHg | |
| Molecular Formula | C26H28O11 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 396.7±32.9 °C | |
Use of T-1095T-1095 is a selective and orally active Na+-glucose cotransporter (SGLT) inhibitor with IC50s of 22.8 µM and 2.3 µM for human SGLT1 and SGLT2, respectively. T-1095 can be used for diabetes research[1]. |
| Name | T-1095 |
|---|---|
| Synonym | More Synonyms |
| Description | T-1095 is a selective and orally active Na+-glucose cotransporter (SGLT) inhibitor with IC50s of 22.8 µM and 2.3 µM for human SGLT1 and SGLT2, respectively. T-1095 can be used for diabetes research[1]. |
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| Related Catalog | |
| Target |
hSGLT1:22.8 μM (IC50) hSGLT2:2.3 μM (IC50) |
| In Vivo | T-1095 is absorbed into the circulation via oral administration, is metabolized to the active form, T-1095A, and suppresses the activity of SGLTs in the kidney[1]. Orally administered T-1095 (3-30 mg/kg) increases urinary glucose excretion in diabetic animals, thereby decreasing blood glucose levels[1]. With long-term T-1095 (0.01% or 0.1% T-1095 mixed diet; for 28 days) treatment, both blood glucose and HbA1c levels were reduced in streptozotocin (STZ)-induced diabetic rats and yellow KK mice. In addition, there was amelioration of abnormal carbohydrate metabolism, i.e., hyperinsulinemia and hypertriglyceridemia, and of the development of microalbuminuria, in yellow KK mice[1]. |
| References |
| Density | 1.4±0.1 g/cm3 |
|---|---|
| Boiling Point | 732.3±60.0 °C at 760 mmHg |
| Molecular Formula | C26H28O11 |
| Molecular Weight | 516.49 |
| Flash Point | 396.7±32.9 °C |
| Exact Mass | 516.163147 |
| LogP | 4.43 |
| Vapour Pressure | 0.0±2.5 mmHg at 25°C |
| Index of Refraction | 1.632 |
| MFCD28404653 |
| 1-Propanone, 3-(5-benzofuranyl)-1-[2-hydroxy-6-[[6-O-(methoxycarbonyl)-β-D-glucopyranosyl]oxy]-4-methylphenyl]- |
| 2-[3-(1-Benzofuran-5-yl)propanoyl]-3-hydroxy-5-methylphenyl 6-O-(methoxycarbonyl)-β-D-glucopyranoside |