MK-6884
Modify Date: 2024-01-09 18:26:15
MK-6884 structure
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Common Name | MK-6884 | ||
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| CAS Number | 2102194-04-5 | Molecular Weight | 411.50 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C25H25N5O | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of MK-6884MK-6884 is a M4 muscarinic receptor positive allosteric modulator (PAM) with a Ki value of 0.19 nM. MK-6884 can be used for the research of the neurodegenerative diseases. MK-6884 can be conveniently radiolabeled with carbon-11 and as a positron emission tomography (PET) imaging agent[1]. |
| Name | MK-6884 |
|---|
| Description | MK-6884 is a M4 muscarinic receptor positive allosteric modulator (PAM) with a Ki value of 0.19 nM. MK-6884 can be used for the research of the neurodegenerative diseases. MK-6884 can be conveniently radiolabeled with carbon-11 and as a positron emission tomography (PET) imaging agent[1]. |
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| Related Catalog | |
| Target |
M4 muscarinic receptor[1] |
| In Vitro | MK-6884 (compound 13; 0-22 µM) is a PAM of ACh function in a cell-based Ca2+ mobilization assay, with an EC50 of 27 nM[1]. |
| In Vivo | [11C]MK-6884 (compound 13) shows non-displaceable binding potential (BPND) of 0.83 in rhesus monkeys[1]. [11C]MK-6884 (approximately 185 MBq, <2 μg; single intravenous) distributes on the known presence of M4 receptors in the rhesus monkeys brain[1]. [11C]MK-688 can penetrate the blood-brain barrier in monkeys[1]. |
| References |
| Molecular Formula | C25H25N5O |
|---|---|
| Molecular Weight | 411.50 |