AB-680
Modify Date: 2024-01-06 12:13:50
AB-680 structure
|
Common Name | AB-680 | ||
|---|---|---|---|---|
| CAS Number | 2105904-82-1 | Molecular Weight | 580.82 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C20H24ClFN4O9P2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of AB-680AB-680 is highly potent, reversible and selective small molecule inhibitor of CD73 (an ecto-nucleotidase), with a Ki of 4.9 pM for hCD73, displays >10,000-fold selectivity over related ecto-nucleotidases CD39. Anti-tumor activity[1]. |
| Name | AB-680 |
|---|
| Description | AB-680 is highly potent, reversible and selective small molecule inhibitor of CD73 (an ecto-nucleotidase), with a Ki of 4.9 pM for hCD73, displays >10,000-fold selectivity over related ecto-nucleotidases CD39. Anti-tumor activity[1]. |
|---|---|
| Related Catalog | |
| Target |
Ki: 4.9 pM (hCD73)[1] IC50: 43 pM (Soluble hCD73)[1] |
| In Vitro | AB-680 (AB680) inhibits soluble hCD73 with an IC50 of 0.043 nM, also inhibits hCD73 in CHO cells, suppresses CD73 in human, mouse CD8+ T Cells and hPBMC, with IC50s of 0.070, 0.008, 0.66 and 0.011 nM, respectively[1]. |
| References |
| Molecular Formula | C20H24ClFN4O9P2 |
|---|---|
| Molecular Weight | 580.82 |
| Storage condition | 2-8°C |
- Shanghai Nianxing Industrial Co., Ltd
- China
- Product Name: CD73 inhibitor AB-680
- Price: Negotiable
- Purity: 98.0%
- Delivery: 10 Day
- Contact: Huang
- Email: sales@echemcloud.com
- DC Chemicals Limited
- China
- Product Name: CD73 inhibitor AB-680
- Price: ￥950.0/100mg ￥1800.0/250mg ￥3900.0/1g
- Purity: 98.0%
- Delivery: 1 Day
- Contact: Tony Cao
- Email: sales@dcchemicals.com
- ShangHai DC Chemicals Co.,Ltd
- China
- Product Name: CD73 inhibitor AB-680
- Price: ￥Inquiry/1g
- Purity: 98.9%
- Delivery: 1 Day
- Contact: Tony Lai
- Email: order@dcchemicals.com
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