2105904-82-1

2105904-82-1 structure

Name: AB-680
Chemical Name: AB-680
CAS Number: 2105904-82-1
Molecular Formula: C₂₀H₂₄ClFN₄O₉P₂
Molecular Weight: 580.82
Catalog: Research Areas Cancer
Create Date: 2019-06-02 09:50:56
Modify Date: 2024-01-06 12:13:50
AB-680 is highly potent, reversible and selective small molecule inhibitor of CD73 (an ecto-nucleotidase), with a Ki of 4.9 pM for hCD73, displays >10,000-fold selectivity over related ecto-nucleotidases CD39. Anti-tumor activity[1].

Name	AB-680

Description	AB-680 is highly potent, reversible and selective small molecule inhibitor of CD73 (an ecto-nucleotidase), with a Ki of 4.9 pM for hCD73, displays >10,000-fold selectivity over related ecto-nucleotidases CD39. Anti-tumor activity[1].
Related Catalog	Research Areas >> Cancer
Target	Ki: 4.9 pM (hCD73)[1] IC50: 43 pM (Soluble hCD73)[1]
In Vitro	AB-680 (AB680) inhibits soluble hCD73 with an IC50 of 0.043 nM, also inhibits hCD73 in CHO cells, suppresses CD73 in human, mouse CD8+ T Cells and hPBMC, with IC50s of 0.070, 0.008, 0.66 and 0.011 nM, respectively[1].
References	[1]. Lawson KV, et al. Discovery and Characterization of AB680, a Potent and Selective Small-Molecule CD73 Inhibitor for Cancer Immunotherapy.