N-(Propargyl-PEG4-carbonyl)-N-bis(PEG1-methyl ester)

Modify Date: 2024-01-21 16:07:50

N-(Propargyl-PEG4-carbonyl)-N-bis(PEG1-methyl ester) Structure
N-(Propargyl-PEG4-carbonyl)-N-bis(PEG1-methyl ester) structure
Common Name N-(Propargyl-PEG4-carbonyl)-N-bis(PEG1-methyl ester)
CAS Number 2112732-01-9 Molecular Weight 519.58
Density N/A Boiling Point N/A
Molecular Formula C24H41NO11 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of N-(Propargyl-PEG4-carbonyl)-N-bis(PEG1-methyl ester)


N-(Propargyl-PEG4-carbonyl)-N-bis(PEG1-methyl ester) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

 Names

Name N-(Propargyl-PEG4-carbonyl)-N-bis(PEG1-methyl ester)
Synonym More Synonyms

  Biological Activity

Description N-(Propargyl-PEG4-carbonyl)-N-bis(PEG1-methyl ester) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog
Target

PEGs

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

 Chemical & Physical Properties

Molecular Formula C24H41NO11
Molecular Weight 519.58

 Safety Information

Hazard Codes Xi

 Synonyms

MFCD30723219