farampator

Modify Date: 2024-01-09 08:21:14

farampator Structure
farampator structure
Common Name farampator
CAS Number 211735-76-1 Molecular Weight 231.251
Density 1.3±0.1 g/cm3 Boiling Point 398.3±34.0 °C at 760 mmHg
Molecular Formula C12H13N3O2 Melting Point N/A
MSDS N/A Flash Point 194.7±25.7 °C

 Use of farampator


Farampator (CX-691;Org24448) is an AMPA receptor positive modulator.

 Names

Name 2,1,3-benzoxadiazol-5-yl(piperidin-1-yl)methanone
Synonym More Synonyms

 farampator Biological Activity

Description Farampator (CX-691;Org24448) is an AMPA receptor positive modulator.
Related Catalog
In Vivo Farampator has potential in treating disorders characterised by cognitive deficits such as Alzheimer's disease and schizophrenia. CX691 attenuates a scopolamine-induced impairment of cued fear conditioning following acute administration (0.1 mg/kg p.o.) and a temporally induced deficit in novel object recognition following both acute (0.1 and 1.0 mg/kg p.o.) and sub-chronic (bi-daily for 7 days) administration (0.01, 0.03, 0.1 mg/kg p.o.). It also improves attentional set-shifting following sub-chronic administration (0.3 mg/kg p.o.)[1]. Farampator (500 mg) unequivocally improves short-term memory but appeares to impair episodic memory. Furthermore, it tends to decrease the number of switching errors in the CTMT. Drug-induced side effects (SEs) included headache, somnolence and nausea. Subjects with SEs has significantly higher plasma levels of farampator than subjects without SEs[2].
Animal Admin Rats: Rats are dosed acutely with CX691 (0.1, 0.3 and 1.0; 2 ml/kg; p.o.) or vehicle (1% methylcellulose; 1 ml/kg; p.o.), and microdialysate samples are collected every 30 min for 4 h post dose. At the end of each experimental day, animals are returned to their home cage and re-used in a randomised cross-over design, allowing at least 7 days drug ishout before subsequent use. After the completion of the final microdialysis experiment, animals are killed, and brains are removed and stored in formalin solution for probe placement verification[1].
References

[1]. Woolley ML, et al. Evaluation of the pro-cognitive effects of the AMPA receptor positive modulator, 5-(1-piperidinylcarbonyl)-2,1,3-benzoxadiazole (CX691), in the rat. Psychopharmacology (Berl). 2009 Jan;202(1-3):343-54.

[2]. Wezenberg E, et al. Acute effects of the ampakine farampator on memory and information processing in healthy elderly volunteers. Neuropsychopharmacology. 2007 Jun;32(6):1272-83.

 Chemical & Physical Properties

Density 1.3±0.1 g/cm3
Boiling Point 398.3±34.0 °C at 760 mmHg
Molecular Formula C12H13N3O2
Molecular Weight 231.251
Flash Point 194.7±25.7 °C
Exact Mass 231.100784
PSA 59.23000
LogP 0.91
Vapour Pressure 0.0±0.9 mmHg at 25°C
Index of Refraction 1.621
Storage condition 2-8℃

 Synonyms

Methanone, 2,1,3-benzoxadiazol-5-yl-1-piperidinyl-
2,1,3-Benzoxadiazol-5-yl(1-piperidinyl)methanone
1-(benzofurazan-5-ylcarbonyl)piperidine
CX-691
UNII-7X6P5N8K2L
Farampator