Acetyl-(Cys3,Nle4,Arg5,D-2-Nal7,Cys11)-α-MSH (3-11) amide trifluoroacetate salt

Modify Date: 2024-01-10 23:17:21

Acetyl-(Cys3,Nle4,Arg5,D-2-Nal7,Cys11)-α-MSH (3-11) amide trifluoroacetate salt Structure
Acetyl-(Cys3,Nle4,Arg5,D-2-Nal7,Cys11)-α-MSH (3-11) amide trifluoroacetate salt structure
Common Name Acetyl-(Cys3,Nle4,Arg5,D-2-Nal7,Cys11)-α-MSH (3-11) amide trifluoroacetate salt
CAS Number 212370-59-7 Molecular Weight 1266.499
Density 1.5±0.1 g/cm3 Boiling Point N/A
Molecular Formula C58H79N19O10S2 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Acetyl-(Cys3,Nle4,Arg5,D-2-Nal7,Cys11)-α-MSH (3-11) amide trifluoroacetate salt


HS024 is a selective MC4 receptor antagonist, with Kis of 0.29, 3.29, 5.45, and 18.6 nM for MC4, MC5, MC3, and MC1, respectively. HS024 increase food intake[1].

 Names

Name hs 024
Synonym More Synonyms

  Biological Activity

Description HS024 is a selective MC4 receptor antagonist, with Kis of 0.29, 3.29, 5.45, and 18.6 nM for MC4, MC5, MC3, and MC1, respectively. HS024 increase food intake[1].
Related Catalog
References

[1]. Kask A, et al. Discovery of a novel superpotent and selective melanocortin-4 receptor antagonist (HS024): evaluation in vitro and in vivo. Endocrinology. 1998;139(12):5006-5014.

 Chemical & Physical Properties

Density 1.5±0.1 g/cm3
Molecular Formula C58H79N19O10S2
Molecular Weight 1266.499
Exact Mass 1265.569824
PSA 550.86000
LogP -1.57
Index of Refraction 1.717

 Synonyms

M.W. 1266.50 C58H79N19O10S2
Neurodazine
1,2-Dithia-5,8,11,14,17,20,23,26-octaazacyclononacosane-4-carboxamide, 28-(acetylamino)-13,22-bis[3-[[(E)-aminoiminomethyl]amino]propyl]-25-butyl-19-(1H-imidazol-4-ylmethyl)-10-(1H-indol-3-ylmethyl)-16-(2-naphthalenylmethyl)-6,9,12,15,18,21,24,27-octaoxo-, (4R,10S,13S,16R,19S,22S,25S,28R)-
AC-CYS-NLE-ARG-HIS-D-2-NAL-ARG-TRP-GLY-CYS-NH2 TRIFLUOROACETATE SALT
HS024
(4R,10S,13S,16R,19S,22S,25S,28R)-28-Acetamido-25-butyl-13,22-bis(3-carbamimidamidopropyl)-19-(1H-imidazol-4-ylmethyl)-10-(1H-indol-3-ylmethyl)-16-(2-naphthylmethyl)-6,9,12,15,18,21,24,27-octaoxo-1,2-dithia-5,8,11,14,17,20,23,26-octaazacyclononacosane-4-carboxamide
AC-CYS-NLE-ARG-HIS-D-2-NAL-ARG-TRP-GLY-CYS-NH2
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