(S)-Indoximod

Modify Date: 2024-01-02 19:24:38

(S)-Indoximod Structure
(S)-Indoximod structure
 Common Name (S)-Indoximod
CAS Number 21339-55-9 Molecular Weight 218.252
Density 1.28 Boiling Point 429.3±35.0 °C at 760 mmHg
Molecular Formula C12H14N2O2 Melting Point 223-226 ºC
MSDS Chinese USA Flash Point 213.4±25.9 °C

 Use of (S)-Indoximod


(S)-Indoximod (1-Methyl-L-tryptophan) is an inhibitor of indoleamine 2,3-dioxygenase (IDO). (S)-Indoximod can be used for the research of cancer[1][2].

 Names

Name (2S)-2-amino-3-(1-methylindol-3-yl)propanoic acid
Synonym More Synonyms

 Chemical & Physical Properties

Density 1.28
Boiling Point 429.3±35.0 °C at 760 mmHg
Melting Point 223-226 ºC
Molecular Formula C12H14N2O2
Molecular Weight 218.252
Flash Point 213.4±25.9 °C
Exact Mass 218.105530
PSA 68.25000
LogP 1.43
Vapour Pressure 0.0±1.1 mmHg at 25°C
Index of Refraction 1.625
Storage condition 2-8°C

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
YN7135000
CHEMICAL NAME :
L-Tryptophan, 1-methyl-
CAS REGISTRY NUMBER :
21339-55-9
LAST UPDATED :
198910
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C12-H14-N2-O2
MOLECULAR WEIGHT :
218.28

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
286 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub., 1025 Vermont Ave., NW, Washington, DC 20005) V.1- 1975/76- Volume(issue)/page/year: 1,515,1976

 Safety Information

Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes Xn
Risk Phrases R20/21/22
Safety Phrases 36
RIDADR NONH for all modes of transport
WGK Germany 3
RTECS YN7135000
HS Code 2933990090

 Synthetic Route

L(-)-Tryptophan structure

L(-)-Tryptophan

CAS#:73-22-3

methyl iodide structure

methyl iodide

CAS#:74-88-4

~92%

(S)-Indoximod Structure

(S)-Indoximod

CAS#:21339-55-9

Literature: He, Bin; Song, Hao; Du, Yu; Qin, Yong Journal of Organic Chemistry, 2009 , vol. 74, # 1 p. 298 - 304
L(-)-Tryptophan structure

L(-)-Tryptophan

CAS#:73-22-3

~%

(S)-Indoximod Structure

(S)-Indoximod

CAS#:21339-55-9

Literature: Bioorganic and Medicinal Chemistry Letters, , vol. 12, # 17 p. 2471 - 2474

 Precursor & DownStream

Precursor  2

DownStream  0

 Customs

HS Code 2933990090
Summary 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

 Articles30

More Articles
Human renal tubular epithelial cells suppress alloreactive T cell proliferation.

Clin. Exp. Immunol. 179(3) , 509-19, (2015)

Renal tubular epithelial cells (TECs) are one of the main targets of alloreactive T cells during acute rejection. We hypothesize that TECs modulate the outcome of alloimmunity by executing immunosuppr...

Induction of indoleamine 2,3-dioxygenase (IDO) enzymatic activity contributes to interferon-gamma induced apoptosis and death receptor 5 expression in human non-small cell lung cancer cells.

Asian Pac. J. Cancer Prev. 15(18) , 7995-8001, (2014)

Interferon-gamma (IFN-γ) has been used to treat various malignant tumors. However, the molecular mechanisms underlying the direct anti-proliferative activity of IFN-γ are poorly understood. In the pre...

Interferon gamma-mediated BoHV-4 replication restriction in bovine endometrial stromal cells is host IDO1 gene expression independent and BoHV-4 IE2 gene expression dependent.

Biol. Reprod. 91(5) , 112, (2014)

In the present work the interaction between bovine herpesvirus 4 (BoHV-4)-infected bovine endometrial stromal cells (BESCs) and interferon gamma (IFNG) was investigated. Starting from the particular t...

 Synonyms

1-Methyl-L-tryptophan
DL-1-Methyltryptophan
MFCD00467133
L-Tryptophan, 1-methyl-
1-methyl-(D,L)-tryptophan
1-Methyl-L-tryptophane
H-L-Trp(N-CH3)-OH
H-Trp(1-Me)-OH
BIDD:GT0440
(S)-2-Amino-3-(1-methyl-1H-indol-3-yl)propanoic acid
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Chemsrc provides (S)-Indoximod(CAS#:21339-55-9) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of (S)-Indoximod are included as well.>> amp version: (S)-Indoximod

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