Pyrroline-5-carboxylate

Modify Date: 2024-01-08 14:39:37

Pyrroline-5-carboxylate Structure
Pyrroline-5-carboxylate structure
Common Name Pyrroline-5-carboxylate
CAS Number 2139-03-9 Molecular Weight 113.11500
Density 1.35g/cm3 Boiling Point 255.5ºC at 760mmHg
Molecular Formula C5H7NO2 Melting Point N/A
MSDS N/A Flash Point 108.3ºC

 Use of Pyrroline-5-carboxylate


Pyrroline-5-carboxylate is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs[1].

 Names

Name 1-pyrroline-2-carboxylic acid
Synonym More Synonyms

 Pyrroline-5-carboxylate Biological Activity

Description Pyrroline-5-carboxylate is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog
Target

Alkyl/ether

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

 Chemical & Physical Properties

Density 1.35g/cm3
Boiling Point 255.5ºC at 760mmHg
Molecular Formula C5H7NO2
Molecular Weight 113.11500
Flash Point 108.3ºC
Exact Mass 113.04800
PSA 49.66000
Vapour Pressure 0.00498mmHg at 25°C
Index of Refraction 1.58

 Safety Information

HS Code 2933990090

 Customs

HS Code 2933990090
Summary 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

 Synonyms

d1-Pyrroline 2-carboxylate
3,4-DIHYDRO-2H-PYRROLIUM-5-CARBOXYLATE
4,5-dihydro-3H-pyrrole-2-carboxylic acid
delta1-Pyrroline 2-carboxylate
1-Pyrroline-2-carboxylic acid
4,5-Dihydro-3H-pyrrol-2-carbonsaeure
3,4-dihydro-2H-pyrrole-5-carboxylic acid
1-Pyrrolin-2-carbonsaeure
1-Pyrroline-2-carboxylate
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