Fidaxomicin-D7

Modify Date: 2024-01-14 20:48:02

Fidaxomicin-D7 Structure
Fidaxomicin-D7 structure
Common Name Fidaxomicin-D7
CAS Number 2143934-06-7 Molecular Weight 1065.08
Density N/A Boiling Point N/A
Molecular Formula C52H67D7Cl2O18 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Fidaxomicin-D7


Fidaxomicin-D7 (OPT-80-D7) is the deuterium labeled Fidaxomicin. Fidaxomicin (OPT-80), a macrocyclic RNA polymerase inhibitor, has a narrow spectrum of activity. Fidaxomicin selectively eradicates pathogenic Clostridium difficile with minimal disruption to the multiple species of bacteria that make up the normal, healthy intestinal flora[1][2].

 Names

Name Fidaxomicin-D7

 Fidaxomicin-D7 Biological Activity

Description Fidaxomicin-D7 (OPT-80-D7) is the deuterium labeled Fidaxomicin. Fidaxomicin (OPT-80), a macrocyclic RNA polymerase inhibitor, has a narrow spectrum of activity. Fidaxomicin selectively eradicates pathogenic Clostridium difficile with minimal disruption to the multiple species of bacteria that make up the normal, healthy intestinal flora[1][2].
Related Catalog
In Vitro Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

[2]. Poxton IR, et al. Fidaxomicin: a new macrocyclic, RNA polymerase-inhibiting antibiotic for the treatment of Clostridium difficile infections. Future Microbiol. 2010 Apr;5(4):539-48.

 Chemical & Physical Properties

Molecular Formula C52H67D7Cl2O18
Molecular Weight 1065.08