Bruceine D

Modify Date: 2024-01-02 12:33:22

Bruceine D structure	Common Name	Bruceine D
	CAS Number	21499-66-1	Molecular Weight	410.415
	Density	1.6±0.1 g/cm3	Boiling Point	661.3±55.0 °C at 760 mmHg
	Molecular Formula	C₂₀H₂₆O₉	Melting Point	N/A
	MSDS	N/A	Flash Point	235.8±25.0 °C

Use of Bruceine D

Bruceine D is a Notch inhibitor with anti-cancer activity and induces apoptosis in several human cancer cells. Bruceine D is an effective botanical insect antifeedant with outstanding systemic properties, causing potent pest growth inhibitory activity[1][2].

Name	bruceine D
Synonym	More Synonyms

Description	Bruceine D is a Notch inhibitor with anti-cancer activity and induces apoptosis in several human cancer cells. Bruceine D is an effective botanical insect antifeedant with outstanding systemic properties, causing potent pest growth inhibitory activity[1][2].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer Research Areas >> Infection Signaling Pathways >> Stem Cell/Wnt >> Notch
Target	Notch[1]
In Vitro	Bruceine D inhibits the cell viability of H460 and A549 cells in a dose-dependent manner with IC50 values of 0.5 and 0.6 μM, respectively, at 48 h of treatment[1]. Bruceine D (0.125-1.0 μM) dose-dependently promotes chromatin condensation, Annexin V-positive cell population and caspase-dependent apoptosis in H460 and A549 cells[1].
References	[1]. Mao G,et al. Bruceine D Isolated from Brucea Javanica (L.) Merr. as a Systemic Feeding Deterrent for Three Major Lepidopteran Pests. J Agric Food Chem. 2019 Apr 17;67(15):4232-4239. [2]. Cheng Z, et al. Bruceine D inhibits hepatocellular carcinoma growth by targeting β-catenin/jagged1 pathways. Cancer Lett. 2017 Sep 10;403:195-205.

Density	1.6±0.1 g/cm3
Boiling Point	661.3±55.0 °C at 760 mmHg
Molecular Formula	C₂₀H₂₆O₉
Molecular Weight	410.415
Flash Point	235.8±25.0 °C
Exact Mass	410.157684
PSA	153.75000
LogP	-0.50
Vapour Pressure	0.0±4.5 mmHg at 25°C
Index of Refraction	1.670
Storage condition	2-8C