NS3861
Modify Date: 2024-01-07 21:58:57
NS3861 structure
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Common Name | NS3861 | ||
|---|---|---|---|---|
| CAS Number | 216853-59-7 | Molecular Weight | 284.22 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C12H14BrNS | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of NS3861NS3861 is an agonist of nicotinic acetylcholine receptors (nAChRs) and binds with high affinity to heteromeric α3β4 nAChR. The binding Ki values of 0.62, 25, 7.8, 55 nM for α3β4, α3β2, α4β4, α4β2, respectively[1]. |
| Name | NS3861 |
|---|
| Description | NS3861 is an agonist of nicotinic acetylcholine receptors (nAChRs) and binds with high affinity to heteromeric α3β4 nAChR. The binding Ki values of 0.62, 25, 7.8, 55 nM for α3β4, α3β2, α4β4, α4β2, respectively[1]. |
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| Related Catalog | |
| In Vitro | NS3861 displays the opposite β-subunit preference and a complete lack of activation at α4-containing receptors in HEK293 cell lines. NS3861 selectively activates α3- but not α4-containing nAChRs and it displays higher efficacy at the α3β2 receptor compared with the α3β4 receptor, with EC50s of 1.7 and 0.15 μM for α3β2 and α3β4 receptor, respectively[1]. NS3861 shows high affinity and partial agonist properties in α3β4-expressed nAChRs[2]. |
| In Vivo | NS3861 enhances fecal pellet expulsion in a dose-dependent manner in mice that received long-term, but not short-term, morphine treatment[2]. |
| References |
| Molecular Formula | C12H14BrNS |
|---|---|
| Molecular Weight | 284.22 |