Varenicline-d4
Modify Date: 2024-01-14 16:47:34
Varenicline-d4 structure
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Common Name | Varenicline-d4 | ||
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| CAS Number | 2183239-01-0 | Molecular Weight | 215.29 | |
| Density | 1.2±0.1 g/cm3 | Boiling Point | 400.6±40.0 °C at 760 mmHg | |
| Molecular Formula | C13H9D4N3 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 196.1±27.3 °C | |
Use of Varenicline-d4Varenicline-d4 is deuterium labeled Varenicline. Varenicline (CP 526555) is a potent partial agonist for α4β2 nicotinic acetylcholine receptor (nAChR) with an EC50 value of 2.3 μM. Varenicline is a full agonist for α3β4 and α7 nAChRs with EC50 values of 55 μM and 18 μM, respectively[1]. Varenicline is a nicotinic ligand based on the structure of cytisine, has the potential for smoking cessation treatment[2]. |
| Name | Varenicline-d4 |
|---|---|
| Synonym | More Synonyms |
| Description | Varenicline-d4 is deuterium labeled Varenicline. Varenicline (CP 526555) is a potent partial agonist for α4β2 nicotinic acetylcholine receptor (nAChR) with an EC50 value of 2.3 μM. Varenicline is a full agonist for α3β4 and α7 nAChRs with EC50 values of 55 μM and 18 μM, respectively[1]. Varenicline is a nicotinic ligand based on the structure of cytisine, has the potential for smoking cessation treatment[2]. |
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| Related Catalog | |
| In Vitro | Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1]. |
| References |
| Density | 1.2±0.1 g/cm3 |
|---|---|
| Boiling Point | 400.6±40.0 °C at 760 mmHg |
| Molecular Formula | C13H9D4N3 |
| Molecular Weight | 215.29 |
| Flash Point | 196.1±27.3 °C |
| Exact Mass | 215.136047 |
| LogP | 0.74 |
| Vapour Pressure | 0.0±0.9 mmHg at 25°C |
| Index of Refraction | 1.667 |
| (13,13,15,15-2H4)-5,8,14-Triazatetracyclo[10.3.1.02,11.04,9]hexadeca-2,4(9),5,7,10-pentaene |
| Varenicline-d4 |
| 6,10-Methano-6H-azepino[4,5-g]quinoxaline-7,9-d2, 7,8,9,10-tetrahydro-7,9-d2- |