Thioquinapiperifil
Modify Date: 2024-01-09 20:44:04
Thioquinapiperifil structure
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Common Name | Thioquinapiperifil | ||
|---|---|---|---|---|
| CAS Number | 220060-39-9 | Molecular Weight | 448.58400 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C24H28N6OS | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of ThioquinapiperifilThioquinapiperifil (KF31327 free base), a potent, selective and non-competitive phosphodiesterase-5 (PDE-5, IC50 of 0.074 nM) inhibitor, is used for sexual enhancement study[1][2]. |
| Name | 3-ethyl-8-[[2-[4-(hydroxymethyl)piperidin-1-yl]phenyl]methylamino]-1H-imidazo[4,5-g]quinazoline-2-thione |
|---|
| Description | Thioquinapiperifil (KF31327 free base), a potent, selective and non-competitive phosphodiesterase-5 (PDE-5, IC50 of 0.074 nM) inhibitor, is used for sexual enhancement study[1][2]. |
|---|---|
| Related Catalog | |
| Target |
PDE5:0.074 nM (IC50) PDE1:380 nM (IC50) PDE2:670 nM (IC50) PDE3:38 nM (IC50) PDE4:800 nM (IC50) |
| In Vitro | Thioquinapiperifil can be found in dietary supplements[1]. Thioquinapiperifil (KF31327 free base) (0.1-10 μM) concentration dependently inhibits platelet aggregation. In the absence of nitroglycerin, higher concentrations 1 and 10 μM of Thioquinapiperifil (KF31327 free base) are required to inhibit platelet aggregation[2]. Thioquinapiperifil (KF31327 free base) and shows significant increase in cyclic GMP at 10 μM. After 5 min incubation, the mean cyclic GMP levels of Thioquinapiperifil (KF31327)-treated cells is 0.95±0.17 pmol/108 cells[2]. |
| References |
| Molecular Formula | C24H28N6OS |
|---|---|
| Molecular Weight | 448.58400 |
| Exact Mass | 448.20500 |
| PSA | 121.13000 |
| LogP | 3.59580 |