Prolyl Hydroxylase inhibitor 1

Modify Date: 2024-01-09 16:12:25

Prolyl Hydroxylase inhibitor 1 structure	Common Name	Prolyl Hydroxylase inhibitor 1
	CAS Number	2205125-60-4	Molecular Weight	415.83
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₉H₁₈ClN₅O₄	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Prolyl Hydroxylase inhibitor 1

Prolyl Hydroxylase inhibitor 1 (Compound 15i) is an orally active hypoxia inducible factor (HIF)-prolyl hydroxylase (PHD) inhibitor with an IC50 of 62.23 nM[1]. Antianemia agent[1].

Name	Prolyl Hydroxylase inhibitor 1

Description	Prolyl Hydroxylase inhibitor 1 (Compound 15i) is an orally active hypoxia inducible factor (HIF)-prolyl hydroxylase (PHD) inhibitor with an IC50 of 62.23 nM[1]. Antianemia agent[1].
Related Catalog	Research Areas >> Cardiovascular Disease Signaling Pathways >> Metabolic Enzyme/Protease >> HIF/HIF Prolyl-Hydroxylase
Target	IC50: 62.23±2.33nM (HIF-PHD)[1]
References	[1]. Wu Y, et al. Click Chemistry-Based Discovery of [3-Hydroxy-5-(1 H-1,2,3-triazol-4-yl)picolinoyl]glycines as Orally Active Hypoxia-Inducing Factor Prolyl Hydroxylase Inhibitors with Favorable Safety Profiles for the Treatment of Anemia. J Med Chem. 2018 Jun 28;61(12):5332-5349.

Molecular Formula	C₁₉H₁₈ClN₅O₄
Molecular Weight	415.83