6-Biopterin

Modify Date: 2024-01-02 10:28:11

6-Biopterin structure	Common Name	6-Biopterin
	CAS Number	22150-76-1	Molecular Weight	237.215
	Density	1.9±0.1 g/cm3	Boiling Point	563.4±60.0 °C at 760 mmHg
	Molecular Formula	C₉H₁₁N₅O₃	Melting Point	>210°C dec.
	MSDS	Chinese USA	Flash Point	294.5±32.9 °C
	Symbol	GHS07	Signal Word	Warning

Use of 6-Biopterin

6-Biopterin (L-Biopterin), a pterin derivative, is a NO synthase cofactor.

Name	biopterin
Synonym	More Synonyms

Description	6-Biopterin (L-Biopterin), a pterin derivative, is a NO synthase cofactor.
Related Catalog	Signaling Pathways >> Immunology/Inflammation >> NO Synthase Natural Products >> Saccharides and Glycosides Research Areas >> Cancer Research Areas >> Neurological Disease
Target	Human Endogenous Metabolite
In Vitro	6-biopterin is extremely cytotoxic to human melanocytes under in vitro conditions. Thioredoxin reductase has the capacity to reduce 6-biopterin to q-BH2 where further reduction to 6-BH4 follows via dihydropteridine reductase or reduced glutathione. (6R)5,6,7,8 tetrahydrobiopterin undergoes redox-cycling by its oxidation to quinonoid dihydrobiopterin and to 6-biopterin through consecutive two electron oxidation reactions[1].
References	[1]. Schallreuter KU, et al. Cytotoxicity of 6-biopterin to human melanocytes. Biochem Biophys Res Commun. 1994 Oct 14;204(1):43-8.

Density	1.9±0.1 g/cm3
Boiling Point	563.4±60.0 °C at 760 mmHg
Melting Point	>210°C dec.
Molecular Formula	C₉H₁₁N₅O₃
Molecular Weight	237.215
Flash Point	294.5±32.9 °C
Exact Mass	237.086182
PSA	138.01000
LogP	-3.84
Vapour Pressure	0.0±1.6 mmHg at 25°C
Index of Refraction	1.822

6-Biopterin MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UO3506000

CHEMICAL NAME :: 4(3H)-Pteridinone, 2-amino-6-(L-erythro-1,2-dihydroxypropyl)-

CAS REGISTRY NUMBER :: 22150-76-1

LAST UPDATED :: 199509

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C9-H11-N5-O3

MOLECULAR WEIGHT :: 237.25

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD - Lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >3 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 879 mg/kg

TOXIC EFFECTS :: Kidney, Ureter, Bladder - changes in bladder weight Endocrine - changes in spleen weight

MUTATION DATA

TEST SYSTEM :: Insect - Drosophila melanogaster

DOSE/DURATION :: 10 ug/L

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 128,147,1984

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H315-H319-H335
Precautionary Statements	P261-P305 + P351 + P338
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xi:Irritant;
Risk Phrases	R36/37/38
Safety Phrases	S26-S36
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	UO3506000
HS Code	2933990090

Precursor 6
CAS#:62933-57-7 1',2'-O-diacety... CAS#:35011-47-3 2,4,5-Triamino-... CAS#:81827-31-8 2-N-ACETYL-1',2... CAS#:1104608-07-2 (1R,2S)-1-(2-am...
CAS#:13039-56-0 5-DEOXY-L-ARABINOSE CAS#:4066-47-1 2,5,6-triamino-...
DownStream 7
CAS#:712-30-1 2-Amino-4-hydro... CAS#:948-60-7 Pterin-6-carbox... CAS#:69056-38-8 (6R)-5,6,7,8-Te... CAS#:13039-82-2 2-amino-6-[(1S,...
CAS#:65434-55-1 2-amino-4-oxo-5... CAS#:62989-33-7 Sapropterin CAS#:62961-57-3 (6S)-Tetrahydro...

HS Code	2933990090
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Circulating tetrahydrobiopterin as a novel biomarker for abdominal aortic aneurysm.

Am. J. Physiol. Heart Circ. Physiol. 307(11) , H1559-64, (2014)

Rupture of abdominal aortic aneurysm (AAA) is unpredictable and lethal. A clinically valid biomarker to monitor the disease has not been available. Based on our recent discoveries that uncoupled endot...

Phenylalanine hydroxylase: function, structure, and regulation.

IUBMB Life 65(4) , 341-9, (2013)

Mammalian phenylalanine hydroxylase (PAH) catalyzes the rate-limiting step in the phenylalanine catabolism, consuming about 75% of the phenylalanine input from the diet and protein catabolism under ph...

Communication between the zinc and tetrahydrobiopterin binding sites in nitric oxide synthase.

Biochemistry 53(25) , 4216-23, (2014)

The nitric oxide synthase (NOS) dimer is stabilized by a Zn(2+) ion coordinated to four symmetry-related Cys residues exactly along the dimer 2-fold axis. Each of the two essential tetrahydrobiopterin...

D-erythro-Biopterin

2-Amino-6-[(1R,2S)-1,2-dihydroxypropyl]-4(1H)-pteridinone

4(1H)-Pteridinone, 2-amino-6-[(1R,2S)-1,2-dihydroxypropyl]-

2-Amino-6-[(1R,2S)-1,2-dihydroxypropyl]pteridin-4(8H)-one

biopterin

MFCD00036787

1,2-Propanediol, 1-(1,2-dihydro-4-hydroxy-2-imino-6-pteridinyl)-, (1R,2S)-

L-Biopterin

Pterin HB2

pterinhb2

(-)-Biopterin

L-Erythro-Biopterin

6-BIOPTERIN

EINECS 244-807-8

(1R,2S)-1-(4-Hydroxy-2-imino-1,2-dihydro-6-pteridinyl)-1,2-propanediol

[S-(R*,S*)]-2-Amino-6-(1,2-dihydroxypropyl)-4(1H)-pteridinone

(1'S,2'R)-Biopterin

Pterin H B2

Shanghai Nianxing Industrial Co., Ltd
China
Product Name: 6-Biopterin
Price: Click To Check
Purity: 98.0%
Delivery: 10 Day
Contact: Yang
Email: sales@echemcloud.com

Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: 6-Biopterin
Price: ￥1968.0/25mg ￥4828.0/100mg ￥628.0/5mg
Purity: 97.0%
Delivery: Inquiry
Contact: Liu jia
Email: 2130147988@qq.com

DC Chemicals Limited
China
Product Name: L-Biopterin
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/500mg
Purity: 98.0%
Delivery: 3 Day
Contact: Tony Cao
Email: sales@dcchemicals.com

ShangHai DC Chemicals Co.,Ltd
China
Product Name: L-Biopterin
Price: ￥Inquiry/1g
Purity: 98.9%
Delivery: 1 Day
Contact: Tony Lai
Email: order@dcchemicals.com

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Price: $66/10mM*1mLinDMSO

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6-Biopterin

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