OBAA
Modify Date: 2024-01-13 10:10:23
OBAA structure
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Common Name | OBAA | ||
|---|---|---|---|---|
| CAS Number | 221632-26-4 | Molecular Weight | 428.647 | |
| Density | 1.0±0.1 g/cm3 | Boiling Point | 558.6±50.0 °C at 760 mmHg | |
| Molecular Formula | C28H44O3 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 305.7±26.6 °C | |
Use of OBAA(2E)-OBAA is a potent phospholipase A2 (PLA2) inhibitor, with an IC50 of 70 nM. (2E)-OBAA induces apoptosis of HUVEC cells. (2E)-OBAA blocks Melittin-induced Ca2+ influx in Trypanosoma brucei, with an IC50 of 0.4 μM[1][2][3][4]. |
| Name | 4-(4-Octadecylphenyl)-4-oxo-2-butenoic acid |
|---|---|
| Synonym | More Synonyms |
| Description | (2E)-OBAA is a potent phospholipase A2 (PLA2) inhibitor, with an IC50 of 70 nM. (2E)-OBAA induces apoptosis of HUVEC cells. (2E)-OBAA blocks Melittin-induced Ca2+ influx in Trypanosoma brucei, with an IC50 of 0.4 μM[1][2][3][4]. |
|---|---|
| Related Catalog | |
| Target |
PLA2:70 nM (IC50) |
| In Vitro | (2E)-OBAA (5.7 μM) induces apoptotic cell death of human umbilical vein endothelial cells (HUVEC). After 16 h of treatment, almost all of the cells has disintegrated into apoptotic bodies[1]. |
| In Vivo | (2E)-OBAA (2.5-7 mg/kg, IV) significantly and dose-dependently inhibits the immunologically induced bronchospasm in guinea pigs[3]. |
| References |
| Density | 1.0±0.1 g/cm3 |
|---|---|
| Boiling Point | 558.6±50.0 °C at 760 mmHg |
| Molecular Formula | C28H44O3 |
| Molecular Weight | 428.647 |
| Flash Point | 305.7±26.6 °C |
| Exact Mass | 428.329041 |
| LogP | 11.09 |
| Vapour Pressure | 0.0±1.6 mmHg at 25°C |
| Index of Refraction | 1.508 |
| (2E)-4-(4-Octadecylphenyl)-4-oxo-2-butenoic acid |
| 2-Butenoic acid, 4-(4-octadecylphenyl)-4-oxo-, (2E)- |
| (2E)-4-(4-Octadecylphenyl)-4-oxobut-2-enoic acid |
| 4-(4-Octadecylphenyl)-4-oxo-2-butenoic acid |