1-Aminocyclobutanecarboxylic acid

Modify Date: 2024-01-02 21:42:17

1-Aminocyclobutanecarboxylic acid Structure
1-Aminocyclobutanecarboxylic acid structure
Common Name 1-Aminocyclobutanecarboxylic acid
CAS Number 22264-50-2 Molecular Weight 115.131
Density 1.3±0.1 g/cm3 Boiling Point 241.1±23.0 °C at 760 mmHg
Molecular Formula C5H9NO2 Melting Point 261ºC (dec.)
MSDS Chinese USA Flash Point 99.6±22.6 °C
Symbol GHS07
GHS07
Signal Word Warning

 Use of 1-Aminocyclobutanecarboxylic acid


1-Aminocyclobutanecarboxylic acid is a NMDA receptor partial agonist acting at the glycine site, NR1[1].

 Names

Name 1-Aminocyclobutanecarboxylic acid
Synonym More Synonyms

 1-Aminocyclobutanecarboxylic acid Biological Activity

Description 1-Aminocyclobutanecarboxylic acid is a NMDA receptor partial agonist acting at the glycine site, NR1[1].
Related Catalog
References

[1]. Atsushi Inanobe, et al. Mechanism of partial agonist action at the NR1 subunit of NMDA receptors. Neuron. 2005 Jul 7;47(1):71-84.

 Chemical & Physical Properties

Density 1.3±0.1 g/cm3
Boiling Point 241.1±23.0 °C at 760 mmHg
Melting Point 261ºC (dec.)
Molecular Formula C5H9NO2
Molecular Weight 115.131
Flash Point 99.6±22.6 °C
Exact Mass 115.063332
PSA 63.32000
LogP -0.62
Vapour Pressure 0.0±1.0 mmHg at 25°C
Index of Refraction 1.540
Storage condition Store at RT

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
GU1336000
CHEMICAL NAME :
Cyclobutanecarboxylic acid, 1-amino-
CAS REGISTRY NUMBER :
22264-50-2
BEILSTEIN REFERENCE NO. :
2802253
LAST UPDATED :
199612
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C5-H9-N-O2
MOLECULAR WEIGHT :
115.15

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD - Lethal dose
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
>500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
BCPCA6 Biochemical Pharmacology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1958- Volume(issue)/page/year: 5,108,1960

 Safety Information

Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H302-H315-H319-H335
Precautionary Statements P261-P305 + P351 + P338
Personal Protective Equipment dust mask type N95 (US);Eyeshields;Faceshields;Gloves
Hazard Codes Xn:Harmful;
Risk Phrases R22;R36/37/38
Safety Phrases S26-S36
RIDADR NONH for all modes of transport
WGK Germany 3
RTECS GU1336000
HS Code 2922499990

 Synthetic Route

~70%

1-Aminocyclobutanecarboxylic acid Structure

1-Aminocyclobut...

CAS#:22264-50-2

Literature: BOEHRINGER INGELHEIM INTERNATIONAL GMBH Patent: WO2005/19158 A1, 2005 ; Location in patent: Page/Page column 18 ;

~40%

1-Aminocyclobutanecarboxylic acid Structure

1-Aminocyclobut...

CAS#:22264-50-2

Literature: Pirrung; Cao; Chen Journal of Organic Chemistry, 1995 , vol. 60, # 18 p. 5790 - 5794

~76%

1-Aminocyclobutanecarboxylic acid Structure

1-Aminocyclobut...

CAS#:22264-50-2

Literature: Gaoni, Yehiel Organic Preparations and Procedures International, 1995 , vol. 27, # 2 p. 185 - 212

 Preparation


 Customs

HS Code 2922499990
Summary HS:2922499990 other amino-acids, other than those containing more than one kind of oxygen function, and their esters; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) MFN tariff:6.5% General tariff:30.0%

 Articles19

More Articles
[Change in the level of 1-aminochloropropane-1-carbonic acid. Activity of a protein inhibitor of polygalacturonase, intensity of formation of oligouronides in apples during ripening and treatment with haloethane derivatives and aminoethoxyvinylglycine].

Prikl. Biokhim. Mikrobiol. 39(4) , 461-4, (2003)

We studied changes in the intensity of ethylene release and accumulation of 1-aminocyclopropane-1-carboxylic acid during ripening of two apple varieties characterized by various physiological states a...

Glycine antagonist action of 1-aminocyclobutane-1-carboxylate (ACBC) in Xenopus oocytes injected with rat brain mRNA.

Eur. J. Pharmacol. 167(2) , 291-4, (1989)

ACBC has been reported to have the binding profile of an antagonist at the glycine site of the NMDA receptor. In Xenopus oocytes injected with rat brain mRNA, we have confirmed the antagonist action o...

Ethylene biosynthesis: processing of a substrate analog supports a radical mechanism for the ethylene-forming enzyme.

Chem. Biol. 5(1) , 49-57, (1998)

The chemical mechanism of the final step of ethylene biosynthesis (the conversion of 1-aminocyclopropanecarboxylic acid, ACC, to ethylene by ACC oxidase, the ethylene-forming enzyme, EFE) is poorly un...

 Synonyms

N-Methylquipazine dimaleate
1-amino-cyclobutanecarboxylicaci
ACBC-OH
MFCD00661068
cb1700
AC4C-OH
Cyclobutanecarboxylic acid, 1-amino-
1-Aminocyclobutaneca
1-Amino-1-carboxycyclobutane
1-Amino-1-cyclobutanecarboxylic acid
1-aminocyclobutane-1-carboxylic acid
1,1-ACCB
1-Aminocyclobutanecarboxylic acid
1-Aminocyclobutan-1-carboxylic acid
aminocyclobutane carboxylic acid
ACBC
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