MFN2 agonist B-A l

Modify Date: 2024-01-03 13:51:35

MFN2 agonist B-A l Structure
MFN2 agonist B-A l structure
 Common Name MFN2 agonist B-A l
CAS Number 2230047-87-5 Molecular Weight 399.557
Density N/A Boiling Point N/A
Molecular Formula C21H29N5OS Melting Point N/A
MSDS N/A Flash Point N/A

 Use of MFN2 agonist B-A l


MFN2 agonist B-A l is a mall-molecule mimics of the peptide-peptide interface of MFN2, allosterically activates MFN2 and promotes mitochondrial fusion with EC50 of 3 nM; potently stimulates mitochondrial fusion in MFN2-deficient cells, competed for minipeptide binding at the MFN2 HR2 interaction site, correct mitochondrial damage induced by nonfunctioning MFN2 mutants by activating endogenous mitofusins by amelioration of mitochondrial dysmotility, fragmentation, depolarization, and clumping; normalizes axonal mitochondrial trafficking within sciatic nerves of MFN2 Thr105→Met105 mice.

 Names

Name MFN2 agonist B-A l

 MFN2 agonist B-A l Biological Activity

Description MFN2 agonist B-A l is a mall-molecule mimics of the peptide-peptide interface of MFN2, allosterically activates MFN2 and promotes mitochondrial fusion with EC50 of 3 nM; potently stimulates mitochondrial fusion in MFN2-deficient cells, competed for minipeptide binding at the MFN2 HR2 interaction site, correct mitochondrial damage induced by nonfunctioning MFN2 mutants by activating endogenous mitofusins by amelioration of mitochondrial dysmotility, fragmentation, depolarization, and clumping; normalizes axonal mitochondrial trafficking within sciatic nerves of MFN2 Thr105→Met105 mice.
References References 1. Rocha AG, et al. Science. 2018 Apr 20;360(6386):336-341. View Related Products by Target Other Targets

 Chemical & Physical Properties

Molecular Formula C21H29N5OS
Molecular Weight 399.557
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