2230047-87-5

2230047-87-5 structure

Name: MFN2 agonist B-A l
Chemical Name: MFN2 agonist B-A l
CAS Number: 2230047-87-5
Molecular Formula: C₂₁H₂₉N₅OS
Molecular Weight: 399.557
Catalog: Research Areas Others
Create Date: 2020-01-11 19:39:28
Modify Date: 2024-01-03 13:51:35
MFN2 agonist B-A l is a mall-molecule mimics of the peptide-peptide interface of MFN2, allosterically activates MFN2 and promotes mitochondrial fusion with EC50 of 3 nM; potently stimulates mitochondrial fusion in MFN2-deficient cells, competed for minipeptide binding at the MFN2 HR2 interaction site, correct mitochondrial damage induced by nonfunctioning MFN2 mutants by activating endogenous mitofusins by amelioration of mitochondrial dysmotility, fragmentation, depolarization, and clumping; normalizes axonal mitochondrial trafficking within sciatic nerves of MFN2 Thr105→Met105 mice.

Name	MFN2 agonist B-A l

Description	MFN2 agonist B-A l is a mall-molecule mimics of the peptide-peptide interface of MFN2, allosterically activates MFN2 and promotes mitochondrial fusion with EC50 of 3 nM; potently stimulates mitochondrial fusion in MFN2-deficient cells, competed for minipeptide binding at the MFN2 HR2 interaction site, correct mitochondrial damage induced by nonfunctioning MFN2 mutants by activating endogenous mitofusins by amelioration of mitochondrial dysmotility, fragmentation, depolarization, and clumping; normalizes axonal mitochondrial trafficking within sciatic nerves of MFN2 Thr105→Met105 mice.
References	References 1. Rocha AG, et al. Science. 2018 Apr 20;360(6386):336-341. View Related Products by Target Other Targets

Molecular Formula	C₂₁H₂₉N₅OS
Molecular Weight	399.557