KDM4-IN-4

Modify Date: 2024-09-20 16:32:01

KDM4-IN-4 Structure
KDM4-IN-4 structure
Common Name KDM4-IN-4
CAS Number 2230475-63-3 Molecular Weight 245.36
Density N/A Boiling Point N/A
Molecular Formula C16H23NO Melting Point N/A
MSDS N/A Flash Point N/A

 Use of KDM4-IN-4


KDM4-IN-4 (compound 47) is a potent histone lysine demethylase 4 (KDM4) inhibitor with a modest affinity binding to ~80 μM for KDM4A-Tudor domain. KDM4-IN-4 can inhibit H3K4Me3 binding to the Tudor domain in cells with an EC50 value of 105 μM. KDM4-IN-4 can be used for researching anticancer[1].

 Names

Name KDM4-IN-4

 KDM4-IN-4 Biological Activity

Description KDM4-IN-4 (compound 47) is a potent histone lysine demethylase 4 (KDM4) inhibitor with a modest affinity binding to ~80 μM for KDM4A-Tudor domain. KDM4-IN-4 can inhibit H3K4Me3 binding to the Tudor domain in cells with an EC50 value of 105 μM. KDM4-IN-4 can be used for researching anticancer[1].
Related Catalog
Target

KDM4A-Tudor domain:80 μM (Ki)

References

[1]. Wu Q, Young B, Wang Y, Davidoff AM, Rankovic Z, Yang J. Recent Advances with KDM4 Inhibitors and Potential Applications. J Med Chem. 2022 Jul 15.

 Chemical & Physical Properties

Molecular Formula C16H23NO
Molecular Weight 245.36