Dual DDR1 and DDR2 inhibitor 5n
Modify Date: 2024-01-07 18:20:03
Dual DDR1 and DDR2 inhibitor 5n structure
|
Common Name | Dual DDR1 and DDR2 inhibitor 5n | ||
|---|---|---|---|---|
| CAS Number | 2241813-33-0 | Molecular Weight | 560.625 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C31H31F3N6O | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of Dual DDR1 and DDR2 inhibitor 5nDual DDR1 and DDR2 inhibitor 5n is a highly potent, selective, dual Discoidin domain receptor DDR1 and DDR2 inhibitor with Kd of 7.9 and 8.0 nM, IC50 of 9.4 and 20.4 nM, repectively; displays significant selectivity against a panel of 403 wild-type kinases at 1 uM (Abl1 IC50=494 nM); dose-dependently inhibited lipopolysaccharide (LPS)-induced interleukin-6 (IL-6) release in mouse primary peritoneal macrophages (MPMs), attenuates lung pathophysiologic changes in LPS-challenged mice, effectively decreases the levels of TNF-α and IL-6 both in BALF and serum. |
| Name | Dual DDR1 and DDR2 inhibitor 5n |
|---|
| Description | Dual DDR1 and DDR2 inhibitor 5n is a highly potent, selective, dual Discoidin domain receptor DDR1 and DDR2 inhibitor with Kd of 7.9 and 8.0 nM, IC50 of 9.4 and 20.4 nM, repectively; displays significant selectivity against a panel of 403 wild-type kinases at 1 uM (Abl1 IC50=494 nM); dose-dependently inhibited lipopolysaccharide (LPS)-induced interleukin-6 (IL-6) release in mouse primary peritoneal macrophages (MPMs), attenuates lung pathophysiologic changes in LPS-challenged mice, effectively decreases the levels of TNF-α and IL-6 both in BALF and serum. |
|---|---|
| References | References 1. Wang Z, et al. J Med Chem. 2018 Aug 3. doi: 10.1021/acs.jmedchem.8b01045. View Related Products by Target Discoidin Domain Receptor (DDR) |
| Molecular Formula | C31H31F3N6O |
|---|---|
| Molecular Weight | 560.625 |