Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: N-[5-(4-Cyanophenyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]-3-pyridinecarboxamide
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

1093222-27-5

1093222-27-5 structure

Name: Pim1/AKK1-IN-1
Chemical Name: N-[5-(4-cyanophenyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]pyridine-3-carboxamide
CAS Number: 1093222-27-5
Molecular Formula: C₂₀H₁₃N₅O
Molecular Weight: 339.35000
Catalog: Signaling Pathways JAK/STAT Signaling Pim
Create Date: 2018-12-26 16:40:09
Modify Date: 2024-01-05 17:34:06
Pim1/AKK1-IN-1 is a potent multi-kinase inhibitor with Kd values of 35 nM/53 nM/75 nM/380 nM for Pim1/AKK1/MST2/LKB1 respectively, and also inhibits MPSK1 and TNIK.

Name	N-[5-(4-cyanophenyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]pyridine-3-carboxamide
Synonyms	3-Pyridinecarboxamide,N-[5-(4-cyanophenyl)-1H-pyrrolo[2,3-b]pyridin-3-yl] CS-0342 LKB1 (AAK1 dual inhibitor) N-[5-(4-Cyanophenyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]-3-pyridinecarboxamide LKB1(AAK1 dual inhibitor)\|\|3-Pyridinecarboxamide,N-[5-(4-cyanophenyl)-1H-pyrrolo[2,3-b]pyridin-3-yl] Pim1/AKK1-IN-1

Description	Pim1/AKK1-IN-1 is a potent multi-kinase inhibitor with Kd values of 35 nM/53 nM/75 nM/380 nM for Pim1/AKK1/MST2/LKB1 respectively, and also inhibits MPSK1 and TNIK.
Related Catalog	Signaling Pathways >> JAK/STAT Signaling >> Pim Research Areas >> Cancer
Target	Kd: 35 nM (Pim1), 53 nM (AKK1), 75 nM (MST2), 380 nM (LKB1)
In Vitro	Pim1/AKK1-IN-1 is multi-kinase inhibitor, and has Kd of 380 nM against LKB1 and 53 nM against AAK1[1].
References	[1]. Bamborough P, et al. Assessment of chemical coverage of kinome space and its implications for kinase drug discovery. J Med Chem. 2008 Dec 25;51(24):7898-914.