SMS2-IN-2 structure
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Common Name | SMS2-IN-2 | ||
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CAS Number | 2241838-28-6 | Molecular Weight | 369.78 | |
Density | N/A | Boiling Point | N/A | |
Molecular Formula | C19H13ClFN3O2 | Melting Point | N/A | |
MSDS | N/A | Flash Point | N/A |
Use of SMS2-IN-2SMS2-IN-2 is a potent, highly selective and orally active sphingomyelin synthase 2 (SMS2) inhibitor, with IC50s of 100 nM and 56 μM for SMS2 and SMS1, respectively. Anti-chronic inflammatory activity[1]. |
Name | SMS2-IN-2 |
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Description | SMS2-IN-2 is a potent, highly selective and orally active sphingomyelin synthase 2 (SMS2) inhibitor, with IC50s of 100 nM and 56 μM for SMS2 and SMS1, respectively. Anti-chronic inflammatory activity[1]. |
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Related Catalog | |
Target |
IC50: 100 nM (SMS2), 56 μM (SMS1)[1] |
In Vivo | SMS2-IN-2 (Compound 15w; 20, 50 mg/kg/day, p.o. for 6 weeks) reduces chronic inflammation in the db/db mice[1]. Animal Model: Type 2 diabetes mellitus (T2DM) db/db mouse model (four-to-five week)[1] Dosage: 20, 50 mg/kg/day Administration: P.O. daily for 6 weeks Result: Significantly reduced IL-6 and insulin levels. |
References |
Molecular Formula | C19H13ClFN3O2 |
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Molecular Weight | 369.78 |