HTT-D3

Modify Date: 2024-04-13 20:19:59

HTT-D3 Structure
HTT-D3 structure
Common Name HTT-D3
CAS Number 2254502-89-9 Molecular Weight 404.48
Density N/A Boiling Point N/A
Molecular Formula C23H25FN6 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of HTT-D3


HTT-D3 is a potent and orally active huntingtin (HTT) splicing modulator. HTT-D3 acts by promoting the inclusion of a pseudoexon containing a premature termination codon (stop-codon psiExon), leading to HTT mRNA degradation and reduction of HTT levels. HTT-D3 reduces p-glycoprotein (P-gp) efflux, and can be uesd for Huntington's disease research[1].

 Names

Name HTT-D3

 HTT-D3 Biological Activity

Description HTT-D3 is a potent and orally active huntingtin (HTT) splicing modulator. HTT-D3 acts by promoting the inclusion of a pseudoexon containing a premature termination codon (stop-codon psiExon), leading to HTT mRNA degradation and reduction of HTT levels. HTT-D3 reduces p-glycoprotein (P-gp) efflux, and can be uesd for Huntington's disease research[1].
Related Catalog
References

[1]. Anuradha Bhattacharyya, et al. Small molecule splicing modifiers with systemic HTT-lowering activity. Nat Commun. 2021 Dec 15;12(1):7299.

 Chemical & Physical Properties

Molecular Formula C23H25FN6
Molecular Weight 404.48
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