Aclerastide

Modify Date: 2024-01-06 20:25:59

Aclerastide Structure
Aclerastide structure
Common Name Aclerastide
CAS Number 227803-63-6 Molecular Weight 913.031
Density 1.5±0.1 g/cm3 Boiling Point N/A
Molecular Formula C42H64N12O11 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Aclerastide


Aclerastide (DSC-127) is an angiotensin receptor agonist. Aclerastide also is a peptide analog of angiotensin II. Aclerastide can be used for the research of tissue regeneration in diabetic ulcers[1][2].

 Names

Name aclerastide
Synonym More Synonyms

 Aclerastide Biological Activity

Description Aclerastide (DSC-127) is an angiotensin receptor agonist. Aclerastide also is a peptide analog of angiotensin II. Aclerastide can be used for the research of tissue regeneration in diabetic ulcers[1][2].
Related Catalog
In Vivo Aclerastide (0.1 mg/wound; day for 5 days) shows superior efficacy in the db/db mouse model of wound healing[1]. Aclerastide (topically administered; 100 μL; once a day; for 14 days) elevates levels of reactive oxygen species and of active MMP-9[2]. Animal Model: db/db mice[2] Dosage: 100 μL Administration: Topically administered, once a day, for 14 days Result: Upregulated reactive oxygen species during inflammation. Increased the levels of the detrimental active MMP-9 in diabetic wounds.

 Chemical & Physical Properties

Density 1.5±0.1 g/cm3
Molecular Formula C42H64N12O11
Molecular Weight 913.031
Exact Mass 912.481750
LogP 1.46
Index of Refraction 1.660

 Synonyms

[3-(L-2-aminohexanoic acid)]angiotensin II-(1-7)-peptide
aclerastide
L-Proline, L-α-aspartyl-N5-(diaminomethylene)-L-ornithyl-L-norleucyl-L-tyrosyl-L-isoleucyl-L-histidyl-
L-α-Aspartyl-L-arginyl-L-norleucyl-L-tyrosyl-L-isoleucyl-L-histidyl-L-proline
UNII:YYD6UT8T47
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