m-PEG11-acid
Modify Date: 2024-01-03 13:00:09
m-PEG11-acid structure
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Common Name | m-PEG11-acid | ||
|---|---|---|---|---|
| CAS Number | 2280998-74-3 | Molecular Weight | 544.63 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C24H48O13 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of m-PEG11-acidm-PEG11-acid is a non-cleavable 11 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. m-PEG11-acid is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[2]. |
| Name | m-PEG11-acid |
|---|
| Description | m-PEG11-acid is a non-cleavable 11 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. m-PEG11-acid is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[2]. |
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| Related Catalog | |
| Target |
PEGs Non-cleavable |
| In Vitro | ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2]. |
| References |
[1]. Wilfried Braje et al. Macrocyclic mcl-1 inhibitors and methods of use. WO2019035927A1. |
| Molecular Formula | C24H48O13 |
|---|---|
| Molecular Weight | 544.63 |
| Storage condition | 2-8°C |