CR 665

Modify Date: 2024-01-11 17:44:53

CR 665 structure	Common Name	CR 665
	CAS Number	228546-92-7	Molecular Weight	671.83200
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₃₆H₄₉N₉O₄	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of CR 665

CR 665 (JNJ 38488502) is a peripherally selective κ-opioid agonist. CR 665 can activate the kappa opioid receptor with EC50 value of 10.9 nM. CR 665 can be used for the research of peripheral pain[1][2].

Name	(2R)-2-[[(2R)-2-[[(2R)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-N-[(2R)-5-(diaminomethylideneamino)-1-oxo-1-(pyridin-4-ylmethylamino)pentan-2-yl]hexanamide
Synonym	More Synonyms

Description	CR 665 (JNJ 38488502) is a peripherally selective κ-opioid agonist. CR 665 can activate the kappa opioid receptor with EC50 value of 10.9 nM. CR 665 can be used for the research of peripheral pain[1][2].
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Opioid Receptor Signaling Pathways >> Neuronal Signaling >> Opioid Receptor Research Areas >> Neurological Disease
Target	C50: 10.9 nM (κ-opioid)[1]
In Vitro	CR 665 exhibits high peripheral to central nervous system (CNS) selectivity[1]. CR 665 can activate the kappa opioid receptor with EC50 value of 10.9 nM[1].

Molecular Formula	C₃₆H₄₉N₉O₄
Molecular Weight	671.83200
Exact Mass	671.39100
PSA	231.17000
LogP	6.67080

UNII-3BX9UG06GG

D-Argininamide,D-phenylalanyl-D-phenylalanyl-D-norleucyl-N-(4-pyridinylmethyl)

CR665

CR 665

Use of CR 665

Names

CR 665 Biological Activity

Chemical & Physical Properties

Synonyms