SET2
Modify Date: 2024-07-12 12:51:20
SET2 structure
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Common Name | SET2 | ||
|---|---|---|---|---|
| CAS Number | 2313525-20-9 | Molecular Weight | 402.44 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C17H21F3N4O2S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of SET2SET2 is a selective TRPV2 antagonist (IC50=0.46 μM). SET2 blocks the TRP channel and suppresses prostate cancer cells migration. SET2 reduces the lysophosphatidic acid (LPA, a TRPV2 activator)-induced cytoplasmic calcium increases[1]. |
| Name | SET 2 |
|---|---|
| Synonym | More Synonyms |
| Description | SET2 is a selective TRPV2 antagonist (IC50=0.46 μM). SET2 blocks the TRP channel and suppresses prostate cancer cells migration. SET2 reduces the lysophosphatidic acid (LPA, a TRPV2 activator)-induced cytoplasmic calcium increases[1]. |
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| Related Catalog | |
| Target |
TRPV2:0.46 μM (IC50) |
| In Vitro | SET2 (20 μM；24 小时) 消除表达 TRPV2 的 PC-3M 细胞的迁移[1]。 SET2 (20 μM；24 小时) 抑制瞬时共转染 TRPV2 和 LPAR1 的 HEK293T 细胞中的 2-APB 诱发电流[1]。 SET2 (20 μM；24 小时) 抑制 LPA (0.1 μM；3 分钟) 诱导的细胞质钙增加和 LPA 诱导的 PC-3M 细胞迁移[1]。 Cell Migration Assay [1] Cell Line: PC-3M prostate cancer cells Concentration: 0, 5 μM, 10 μM, and 20 μM Incubation Time: 24 hr and 48 hr Result: Inhibited cell migration of PC-3M cells, without inhibiting cell viability at 48 hours. |
| References |
| Molecular Formula | C17H21F3N4O2S |
|---|---|
| Molecular Weight | 402.44 |
| N-(2-Furanylmethyl)-3-[[4-(methylpropylamino)-6-(trifluoromethyl)-2-pyrimidinyl]thio]propanamide |