1H,12H-Benzo[i]pyrano[3,4-g]indolizin-12-one,2,3,5,6,8,9,10,13-octahydro-2-methoxy-, (2S,13bS)-

Modify Date: 2024-01-16 23:53:21

1H,12H-Benzo[i]pyrano[3,4-g]indolizin-12-one,2,3,5,6,8,9,10,13-octahydro-2-methoxy-, (2S,13bS)- structure	Common Name	1H,12H-Benzo[i]pyrano[3,4-g]indolizin-12-one,2,3,5,6,8,9,10,13-octahydro-2-methoxy-, (2S,13bS)-
	CAS Number	23255-54-1	Molecular Weight	275.34300
	Density	1.25g/cm3	Boiling Point	486.6ºC at 760 mmHg
	Molecular Formula	C₁₆H₂₁NO₃	Melting Point	N/A
	MSDS	N/A	Flash Point	248.1ºC

Use of 1H,12H-Benzo[i]pyrano[3,4-g]indolizin-12-one,2,3,5,6,8,9,10,13-octahydro-2-methoxy-, (2S,13bS)-

Dihydro-β-erythroidine is a a competitive nicotinic receptor antagonist. Dihydro-β-erythroidine blocks the discriminative stimulus properties of nicotine. Dihydro-β-erythroidine inhibits the anxiolytic effect of nicotine induced[1][2].

Name	dihydro-β-erythroidine
Synonym	More Synonyms

Description	Dihydro-β-erythroidine is a a competitive nicotinic receptor antagonist. Dihydro-β-erythroidine blocks the discriminative stimulus properties of nicotine. Dihydro-β-erythroidine inhibits the anxiolytic effect of nicotine induced[1][2].
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> nAChR Signaling Pathways >> Neuronal Signaling >> nAChR Research Areas >> Neurological Disease
In Vivo	Dihydro-β-erythroidine (0.5, 1.6, 5.0 mg/kg; s.c.) blocks the discriminative stimulus properties of nicotine in rats[1]. Dihydro-β-erythroidine (100 ng) shows antagonism of the anxiolytic effect of nicotine in the dorsal raphe´ nucleus in rats[2]. Animal Model: 200-250 g male hooded Lister rats[1] Dosage: 0.5, 1.6, 5.0 mg/kg Administration: S.c. Result: Prevented the development of CTAs (conditioned taste aversion) and blocked the discriminative stimulus effect of nicotine (0.2 or 0.4 mg/kg SC) for 45 min after its administration.
References	[1]. Shoaib M, et al. Antagonism of stimulus properties of nicotine by dihydro-beta-erythroidine (DHbetaE) in rats. Psychopharmacology (Berl). 2000 Apr;149(2):140-6. [2]. Cheeta S, et al. Antagonism of the anxiolytic effect of nicotine in the dorsal raphe nucleus by dihydro-beta-erythroidine. Pharmacol Biochem Behav. 2001 Dec;70(4):491-6.

Density	1.25g/cm3
Boiling Point	486.6ºC at 760 mmHg
Molecular Formula	C₁₆H₂₁NO₃
Molecular Weight	275.34300
Flash Point	248.1ºC
Exact Mass	275.15200
PSA	38.77000
LogP	1.75120
Vapour Pressure	1.27E-09mmHg at 25°C
Index of Refraction	1.592

CHEMICAL IDENTIFICATION

RTECS NUMBER :: KF3150000

CHEMICAL NAME :: beta-Erythroidine, dihydro-

CAS REGISTRY NUMBER :: 23255-54-1

BEILSTEIN REFERENCE NO. :: 0036193

LAST UPDATED :: 199612

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C16-H21-N-O3

MOLECULAR WEIGHT :: 275.38

WISWESSER LINE NOTATION :: T B6656 1A Q AX DVO JN XU XUTJ PO1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 4500 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 113,212,1955

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 3 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: RISSAF Rendiconti Istituto Superiore di Sanita (Italian Edition). (Rome, Italy) V.4-27, 1941-64. Volume(issue)/page/year: 12,158,1949

dihydro-beta-erythroidine

1-(2,6,6-trimethyl-1-cyclohexen-1-yl)butan-1-one

.β.-Erythroidine, dihydro-

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(12S,13aS)-)-12-methoxy-1,4,5,6,9,11,12,13-octahydro-8H-pyrano[4',3':3,4]pyrido[2,1-i]indol-2-one

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1H,12H-Benzo[i]pyrano[3,4-g]indolizin-12-one,2,3,5,6,8,9,10,13-octahydro-2-methoxy-, (2S,13bS)-

Use of 1H,12H-Benzo[i]pyrano[3,4-g]indolizin-12-one,2,3,5,6,8,9,10,13-octahydro-2-methoxy-, (2S,13bS)-

Names

Biological Activity

Chemical & Physical Properties

Toxicological Information

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

Synonyms