Bay 36-7620

Modify Date: 2024-01-07 17:43:58

Bay 36-7620 Structure
Bay 36-7620 structure
 Common Name Bay 36-7620
CAS Number 232605-26-4 Molecular Weight 278.35
Density N/A Boiling Point 471.861ºC at 760 mmHg
Molecular Formula C19H18O2 Melting Point N/A
MSDS N/A Flash Point 199.799ºC

 Use of Bay 36-7620


BAY 36-7620 is a potent and noncompetitive antagonist of mGlu1 Receptor (IC50=0.16 μM) with inverse agonist activity. BAY 36-7620 inhibits tumor growth and prolongs the survival of mice with tumors by inhibiting mGlu1 receptor. BAY 36-7620 suppresses AKT phosphorylation in A549 tumors. BAY 36-762 has neuroprotective effect in acute subdural hematoma rat model.BAY 36-7620 is used in non-small cell lung cancer and breast cancer research[1][2][3][4].

 Names

Name (3aS,6aS)-5-methylidene-3a-(naphthalen-2-ylmethyl)-1,4,6,6a-tetrahydrocyclopenta[c]furan-3-one
Synonym More Synonyms

 Bay 36-7620 Biological Activity

Description BAY 36-7620 is a potent and noncompetitive antagonist of mGlu1 Receptor (IC50=0.16 μM) with inverse agonist activity. BAY 36-7620 inhibits tumor growth and prolongs the survival of mice with tumors by inhibiting mGlu1 receptor. BAY 36-7620 suppresses AKT phosphorylation in A549 tumors. BAY 36-762 has neuroprotective effect in acute subdural hematoma rat model.BAY 36-7620 is used in non-small cell lung cancer and breast cancer research[1][2][3][4].
Related Catalog
Target

mGluR 1:0.16 μM (IC50)

mGluR1a:0.38 μM (IC50)

mGluR2:0.14 μM (IC50)

mGluR 5:0.24 μM (IC50)

References

[1]. Carroll FY, et al. BAY36-7620: a potent non-competitive mGlu1 receptor antagonist with inverse agonist activity. Mol Pharmacol. 2001 May;59(5):965-73.  

[2]. Xia H, et al. Inhibition of metabotropic glutamate receptor 1 suppresses tumor growth and angiogenesis in experimental non-small cell lung cancer. Eur J Pharmacol. 2016 Jul 15;783:103-11.  

[3]. Dolfi SC, et al. Riluzole exerts distinct antitumor effects from a metabotropic glutamate receptor 1-specific inhibitor on breast cancer cells. Oncotarget. 2017 Jul 4;8(27):44639-44653.  

[4]. De Vry J, et al. Neuroprotective and behavioral effects of the selective metabotropic glutamate mGlu(1) receptor antagonist BAY 36-7620. Eur J Pharmacol. 2001 Oct 5;428(2):203-14.  

 Chemical & Physical Properties

Boiling Point 471.861ºC at 760 mmHg
Molecular Formula C19H18O2
Molecular Weight 278.35
Flash Point 199.799ºC
Exact Mass 278.13100
PSA 26.30000
LogP 3.89170
Vapour Pressure 0mmHg at 25°C
Index of Refraction 1.633

 Synonyms

hms3269k21
bay-36-7620
unii-0p934rsf8b
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Chemsrc provides Bay 36-7620(CAS#:232605-26-4) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of Bay 36-7620 are included as well.>> amp version: Bay 36-7620

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