(-)-perillic acid

Modify Date: 2024-01-02 09:51:19

(-)-perillic acid structure	Common Name	(-)-perillic acid
	CAS Number	23635-14-5	Molecular Weight	166.21700
	Density	1.068g/cm3	Boiling Point	284.9ºC at 760mmHg
	Molecular Formula	C₁₀H₁₄O₂	Melting Point	129-131ºC(lit.)
	MSDS	Chinese USA	Flash Point	134ºC
	Symbol	GHS07	Signal Word	Warning

Use of (-)-perillic acid

(S)-(-)-Perillic acid is a terpenoid plant extract with antimicrobial and anticancer activities. (S)-(-)-Perillic acid induces cell apoptosis and cell cycle arrest, and increases the levell of Bax, Bcl2, p21 and caspase-3 proteins. (S)-(-)-Perillic acid can be used for cancer and infection research[1][2][3].

Name	(4S)-4-prop-1-en-2-ylcyclohexene-1-carboxylic acid
Synonym	More Synonyms

Description	(S)-(-)-Perillic acid is a terpenoid plant extract with antimicrobial and anticancer activities. (S)-(-)-Perillic acid induces cell apoptosis and cell cycle arrest, and increases the levell of Bax, Bcl2, p21 and caspase-3 proteins. (S)-(-)-Perillic acid can be used for cancer and infection research[1][2][3].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer Research Areas >> Infection Signaling Pathways >> Anti-infection >> Bacterial
In Vitro	(S)-(-)-Perillic acid (1.0-3.5 mM；24，48 和 72 小时) 时间和剂量依赖性地抑制动脉平滑肌细胞 (SMCs) 的生长[1]。 (S)-(-)-Perillic acid (1.0-3.5 mM；20 小时) 剂量依赖性地抑制大鼠动脉平滑肌细胞 (SMC) 胸腺嘧啶核内结合[1]。 (S)-(-)-Perillic acid (2.5 mM；24 小时) 阻滞 G0/G1 期细胞周期进程，诱导动脉平滑肌细胞凋亡[1]。 (S)-(-)-Perillic acid (1.0-3.5 mM；20小时) 剂量依赖性抑制 [3H]FOH 和[3H]GGOH 掺入特定低分子量蛋白[1]。 (S)-(-)-Perillic acid (0.5 mM；24小时) 提高 H520 细胞中 Bax，Bcl2，p21 和 caspase-3 蛋白水平[2]。 Cell Viability Assay[2] Cell Line: Human lung cancer A549 cell line Concentration: 0-5 mM Incubation Time: 24 hour Result: Inhibited long-term proliferation of A549 cells with an IC50 value of 3.6 mM.
References	[1]. Ferri N, et al. Effect of S(-) perillic acid on protein prenylation and arterial smooth muscle cell proliferation. Biochem Pharmacol. 2001 Dec 15;62(12):1637-45. [2]. Yeruva L, et al. Perillyl alcohol and perillic acid induced cell cycle arrest and apoptosis in non small cell lung cancer cells. Cancer Lett. 2007 Nov 18;257(2):216-26. [3]. Khandelia H, et al. Interaction of salicylate and a terpenoid plant extract with model membranes: reconciling experiments and simulations. Biophys J. 2010 Dec 15;99(12):3887-94.

Density	1.068g/cm3
Boiling Point	284.9ºC at 760mmHg
Melting Point	129-131ºC(lit.)
Molecular Formula	C₁₀H₁₄O₂
Molecular Weight	166.21700
Flash Point	134ºC
Exact Mass	166.09900
PSA	37.30000
LogP	2.37360
Vapour Pressure	0.000746mmHg at 25°C
Storage condition	2-8°C

(-)-perillic acid MSDS(Chinese)

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H315-H319-H335
Precautionary Statements	P261-P305 + P351 + P338
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xi: Irritant;
Risk Phrases	36/37/38
Safety Phrases	26-36
RIDADR	NONH for all modes of transport
WGK Germany	3
HS Code	29162000

Precursor 8
CAS#:536-59-4 UNII:319R5C7293 CAS#:18031-40-8 (-)-Perillaldehyde CAS#:7785-70-8 (+)-alpha-Pinene CAS#:18172-67-3 Beta-pinene
CAS#:127-91-3 β-pinene CAS#:852920-51-5 Spiro[bicyclo[3... CAS#:6931-54-0 2,10-epoxypinane CAS#:76509-36-9 (S)-8-bromo-p-m...
DownStream 1
CAS#:26460-67-3 METHYL PERILLATE