JHU 37160

Modify Date: 2024-07-07 13:04:23

JHU 37160 Structure
JHU 37160 structure
Common Name JHU 37160
CAS Number 2369979-68-8 Molecular Weight 358.8403
Density N/A Boiling Point N/A
Molecular Formula C19H20ClFN4 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of JHU 37160


JHU37160 is a potent and brain-penetrant DREADD agonist, with EC50s of 18.5 nM and 0.2 nM for hM3Dq and hM4Di DREADDs in HEK-293 cells, respectively. JHU37160 exhibits selective [3H]Clozapine displacement from DREADDs and not from other Clozapine-binding sites in mice brain tissue.

 Names

Name JHU37160
Synonym More Synonyms

 JHU 37160 Biological Activity

Description JHU37160 is a potent and brain-penetrant DREADD agonist, with EC50s of 18.5 nM and 0.2 nM for hM3Dq and hM4Di DREADDs in HEK-293 cells, respectively. JHU37160 exhibits selective [3H]Clozapine displacement from DREADDs and not from other Clozapine-binding sites in mice brain tissue.

 Chemical & Physical Properties

Molecular Formula C19H20ClFN4
Molecular Weight 358.8403

 Synonyms

MFCD20727945
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