10-Cl-BBQ

Modify Date: 2024-01-14 07:12:51

10-Cl-BBQ structure	Common Name	10-Cl-BBQ
	CAS Number	23982-76-5	Molecular Weight	304.73
	Density	1.5±0.1 g/cm3	Boiling Point	636.8±47.0 °C at 760 mmHg
	Molecular Formula	C₁₈H₉ClN₂O	Melting Point	N/A
	MSDS	N/A	Flash Point	338.9±29.3 °C

Use of 10-Cl-BBQ

10-Cl-BBQ is a high affinity AhR ligand with immunosuppressive activity. 10-Cl-BBQ promotes cytosol to nuclear translocation of AhR and activates the AhR-regulated reporter gene at nanomolar concentrations[1][2].

Name	10-Cl-BBQ
Synonym	More Synonyms

Description	10-Cl-BBQ is a high affinity AhR ligand with immunosuppressive activity. 10-Cl-BBQ promotes cytosol to nuclear translocation of AhR and activates the AhR-regulated reporter gene at nanomolar concentrations[1][2].
Related Catalog	Signaling Pathways >> Immunology/Inflammation >> Aryl Hydrocarbon Receptor Research Areas >> Inflammation/Immunology
References	[1]. Sumit Punj, et al. Benzimidazoisoquinolines: a new class of rapidly metabolized aryl hydrocarbon receptor (AhR) ligands that induce AhR-dependent Tregs and prevent murine graft-versus-host disease. PLoS One. 2014 Feb 19;9(2):e88726. [2]. Allison K Ehrlich, et al. Activation of the Aryl Hydrocarbon Receptor by 10-Cl-BBQ Prevents Insulitis and Effector T Cell Development Independently of Foxp3+ Regulatory T Cells in Nonobese Diabetic Mice. J Immunol. 2016 Jan 1;196(1):264-73.

Description

Related Catalog

Signaling Pathways >> Immunology/Inflammation >> Aryl Hydrocarbon Receptor

Research Areas >> Inflammation/Immunology

References

[1]. Sumit Punj, et al. Benzimidazoisoquinolines: a new class of rapidly metabolized aryl hydrocarbon receptor (AhR) ligands that induce AhR-dependent Tregs and prevent murine graft-versus-host disease. PLoS One. 2014 Feb 19;9(2):e88726.

[2]. Allison K Ehrlich, et al. Activation of the Aryl Hydrocarbon Receptor by 10-Cl-BBQ Prevents Insulitis and Effector T Cell Development Independently of Foxp3+ Regulatory T Cells in Nonobese Diabetic Mice. J Immunol. 2016 Jan 1;196(1):264-73.

Density	1.5±0.1 g/cm3
Boiling Point	636.8±47.0 °C at 760 mmHg
Molecular Formula	C₁₈H₉ClN₂O
Molecular Weight	304.73
Flash Point	338.9±29.3 °C
Exact Mass	304.040344
LogP	5.05
Vapour Pressure	0.0±1.9 mmHg at 25°C
Index of Refraction	1.786

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10-Chloro-7H-benzimidazo[2,1-a]benzo[de]isoquinolin-7-one

7H-Benzimidazo[2,1-a]benz[de]isoquinolin-7-one, 10-chloro-

7H-[1,3]Benzimidazo[2,1-a]benzo[de]isoquinolin-7-one, 10-chloro-

10-Cl-BBQ

10-Cl-BBQ

Use of 10-Cl-BBQ

Names

10-Cl-BBQ Biological Activity

Chemical & Physical Properties

Synonyms