FGFR1 inhibitor-2

Modify Date: 2024-01-06 14:16:05

FGFR1 inhibitor-2 Structure
FGFR1 inhibitor-2 structure
Common Name FGFR1 inhibitor-2
CAS Number 2410612-08-5 Molecular Weight 507.45
Density N/A Boiling Point N/A
Molecular Formula C25H22F5N3O3 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of FGFR1 inhibitor-2


FGFR1 inhibitor-2 is a FGFR1 inhibitor (IC50 is 4.55 μM in MDA-MB-231 cells). FGFR1 inhibitor-2 can be used for the research of metastatic triple-negative breast cancer[1].

 Names

Name FGFR1 inhibitor-2

 FGFR1 inhibitor-2 Biological Activity

Description FGFR1 inhibitor-2 is a FGFR1 inhibitor (IC50 is 4.55 μM in MDA-MB-231 cells). FGFR1 inhibitor-2 can be used for the research of metastatic triple-negative breast cancer[1].
Related Catalog
Target

FGFR1

In Vitro FGFR1 inhibitor-2 (3 and 6 μM; 48 hours; MDA-MB-231) reduces the expression of FGFR1[1]. FGFR1 inhibitor-2 (0~5 μM; MDA-MB-231) increases the apoptotic index by 10.6-fold at 5 μM[1]. Western Blot Analysis[1] Cell Line: MDA-MB-231 Concentration: 3 and 6 μM Incubation Time: 48 hours Result: Reduced the expression of FGFR1.
References

[1]. Ashraf-Uz-Zaman M, et al. Design, synthesis and structure-activity relationship study of novel urea compounds as FGFR1 inhibitors to treat metastatic triple-negative breast cancer. Eur J Med Chem. 2021;209:112866.

 Chemical & Physical Properties

Molecular Formula C25H22F5N3O3
Molecular Weight 507.45
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