Febrifugine

Modify Date: 2024-01-02 11:31:19

Febrifugine Structure
Febrifugine structure
Common Name Febrifugine
CAS Number 24159-07-7 Molecular Weight 301.340
Density 1.4±0.1 g/cm3 Boiling Point 508.2±60.0 °C at 760 mmHg
Molecular Formula C16H19N3O3 Melting Point 139-140°; mp 154-156°
MSDS N/A Flash Point 261.1±32.9 °C

 Use of Febrifugine


Febrifugine is a quinazolinone alkaloid found in the roots and leaves of Dichroa febrifuga, with antimalarial activity [1].

 Names

Name Febrifugine
Synonym More Synonyms

 Chemical & Physical Properties

Density 1.4±0.1 g/cm3
Boiling Point 508.2±60.0 °C at 760 mmHg
Melting Point 139-140°; mp 154-156°
Molecular Formula C16H19N3O3
Molecular Weight 301.340
Flash Point 261.1±32.9 °C
Exact Mass 301.142639
PSA 84.22000
LogP -0.04
Vapour Pressure 0.0±1.4 mmHg at 25°C
Index of Refraction 1.673
Storage condition 2-8℃

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
VA3450000
CHEMICAL NAME :
4(3H)-Quinazolinone, 3-(3-(3-hydroxy-2-piperidinyl)-2-oxopropyl)-, (2S-trans)-
CAS REGISTRY NUMBER :
24159-07-7
LAST UPDATED :
199707
DATA ITEMS CITED :
3
MOLECULAR FORMULA :
C16-H19-N3-O3
MOLECULAR WEIGHT :
301.38
WISWESSER LINE NOTATION :
T66 BVN ENJ C1V1- BT6NTJ CQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
2500 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JACSAT Journal of the American Chemical Society. (American Chemical Soc., Distribution Office Dept. 223, POB 57136, West End Stn., Washington, DC 20037) V.1- 1879- Volume(issue)/page/year: 71,1048,1949
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
10 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 13,867,1970
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
4600 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NATUAS Nature. (Nature Subscription Dept., POB 1018, Manasguan, NJ 08736) V.1- 1869- Volume(issue)/page/year: 161,400,1948

 Safety Information

HS Code 2933990090

 Synthetic Route

 Customs

HS Code 2933990090
Summary 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

 Synonyms

3-{3-[(2S,3R)-3-Hydroxypiperidin-2-yl]-2-oxopropyl}quinazolin-4(3H)-one
3-[b-Keto-g-(3-hydroxy-2-piperidyl)propyl]-4-quinazolone
(2S-trans)-3-[3-(3-Hydroxy-2-piperidinyl)-2-oxopropyl]-4(3H)-quinazolinone
3-{3-[(2S,3R)-3-Hydroxy-2-piperidinyl]-2-oxopropyl}-4(3H)-quinazolinone
b-Dichroine
β-Dichroine
4(3H)-Quinazolinone, 3-[3-[(2S,3R)-3-hydroxy-2-piperidinyl]-2-oxopropyl]-
Febrifugine
febrifungine
Febrifugine (8CI)
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