S65487 sulfate
Modify Date: 2024-01-02 21:08:24
S65487 sulfate structure
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Common Name | S65487 sulfate | ||
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| CAS Number | 2416937-01-2 | Molecular Weight | 815.33 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C41H43ClN6O8S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of S65487 sulfateS65487 (VOB560) sulfate is a potent and selective Bcl-2 inhibitor. S65487 sulfate is also active on BCL-2 mutations, such as G101V and D103Y. S65487 sulfate has poor affinity with MCL-1, BFL-1 and BCL-XL. S65487 sulfate induces apoptosis and has anticaner activities[1][2]. |
| Name | S65487 sulfate |
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| Description | S65487 (VOB560) sulfate is a potent and selective Bcl-2 inhibitor. S65487 sulfate is also active on BCL-2 mutations, such as G101V and D103Y. S65487 sulfate has poor affinity with MCL-1, BFL-1 and BCL-XL. S65487 sulfate induces apoptosis and has anticaner activities[1][2]. |
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| Related Catalog | |
| In Vitro | S65487 binds to the BH3 hydrophobic groove of BCL-2. S65487 induces apoptosis in a panel of hematological cancer cell lines and inhibits cell proliferation with IC50s in the low nM range[1]. |
| In Vivo | S65487 induces complete regression in BCL-2-dependent RS4;11 tumors in vivo after a single IV (intravenous) administration. Strong and persistent tumor regression in xenograft models of lymphoid malignancies in mouse and rat are observed at well tolerated doses following weekly IV administration of S65487 in combination with the MCL-1-specific inhibitor, S64315/MIK665[1]. |
| References |
| Molecular Formula | C41H43ClN6O8S |
|---|---|
| Molecular Weight | 815.33 |