Valpromide

Modify Date: 2024-01-05 01:56:50

Valpromide structure	Common Name	Valpromide
	CAS Number	2430-27-5	Molecular Weight	143.22700
	Density	0.885g/cm3	Boiling Point	274.6ºC at 760mmHg
	Molecular Formula	C₈H₁₇NO	Melting Point	123-125°C
	MSDS	Chinese USA	Flash Point	119.9ºC
	Symbol	GHS07	Signal Word	Warning

Use of Valpromide

Valpromide is an amide derivative of valproic acid and inhibits human epoxide hydrolase.

Name	valpromide
Synonym	More Synonyms

Description	Valpromide is an amide derivative of valproic acid and inhibits human epoxide hydrolase.
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Infection Research Areas >> Neurological Disease
Target	epoxide hydrolase[1]
References	[1]. Pacifici GM, et al. Valpromide inhibits human epoxide hydrolase. Br J Clin Pharmacol. 1986 Sep;22(3):269-74. [2]. Gorres KL, et al. Valpromide Inhibits Lytic Cycle Reactivation of Epstein-Barr Virus. MBio. 2016 Mar 1;7(2):e00113.

Density	0.885g/cm3
Boiling Point	274.6ºC at 760mmHg
Melting Point	123-125°C
Molecular Formula	C₈H₁₇NO
Molecular Weight	143.22700
Flash Point	119.9ºC
Exact Mass	143.13100
PSA	43.09000
LogP	2.38840
Vapour Pressure	0.00535mmHg at 25°C
Index of Refraction	1.44
Storage condition	room temp

Valpromide MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: YV5965500

CHEMICAL NAME :: Valeramide, 2-propyl-

CAS REGISTRY NUMBER :: 2430-27-5

BEILSTEIN REFERENCE NO. :: 1750444

LAST UPDATED :: 199612

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C8-H17-N-O

MOLECULAR WEIGHT :: 143.26

WISWESSER LINE NOTATION :: ZVY3&3

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 890 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 85GNAW "Pharmacodynamie de l'Acide Dipropylacetique (ou Propyl-2-Pentanoique) et de ses Amides," Carraz, G., Imprimerie Eymond, 1968 Volume(issue)/page/year: -,72,1968

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 950 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 85GNAW "Pharmacodynamie de l'Acide Dipropylacetique (ou Propyl-2-Pentanoique) et de ses Amides," Carraz, G., Imprimerie Eymond, 1968 Volume(issue)/page/year: -,71,1968

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 438 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CYLPDN Zhongguo Yaoli Xuebao. Acta Pharmacologica Sinica. Chinese Journal of Pharmacology. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.1- 1980- Volume(issue)/page/year: 9,37,1988 ** REPRODUCTIVE DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 600 mg/kg

SEX/DURATION :: female 8 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - fetal death

REFERENCE :: FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year: 6,669,1986

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H302
Hazard Codes	Xn
Risk Phrases	R22
Safety Phrases	S22-S36/37
RIDADR	NONH for all modes of transport
RTECS	YV5965500
HS Code	2924199090

HS Code	2924199090
Summary	2924199090. other acyclic amides (including acyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

The synergistic effects of DNA-damaging drugs cisplatin and etoposide with a histone deacetylase inhibitor valproate in high-risk neuroblastoma cells.

Int. J. Oncol. 47 , 343-52, (2015)

High-risk neuroblastoma remains one of the most important therapeutic challenges for pediatric oncologists. New agents or regimens are urgently needed to improve the treatment outcome of this fatal tu...

Amidic modification of valproic acid reduces skeletal teratogenicity in mice.

Birth Defects Res. B Dev. Reprod. Toxicol. 71(1) , 47-53, (2004)

The antiepileptic drug valproic acid (VPA) is well known to cause neural tube and skeletal defects in both humans and animals. The amidic VPA analogues valpromide (VPD) and valnoctamide (VCD) have muc...

Polycomb homologs are involved in teratogenicity of valproic acid in mice.

Birth Defects Res. A Clin. Mol. Teratol. 70(11) , 870-9, (2004)

Valproic acid (VPA) is widely used to treat epilepsy and bipolar disorder and is also a potent teratogen, but its teratogenic mechanisms are unknown. We have attempted to describe a fundamental role o...

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EINECS 219-394-2

MFCD00051534

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China
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DC Chemicals Limited
China
Product Name: Valpromide
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Purity: 98.0%
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Price: $66/10mM*1mLinDMSO

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Valpromide

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