Pipamperone Dihydrochloride
Modify Date: 2024-01-03 14:31:52
Pipamperone Dihydrochloride structure
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Common Name | Pipamperone Dihydrochloride | ||
|---|---|---|---|---|
| CAS Number | 2448-68-2 | Molecular Weight | 448.40 | |
| Density | N/A | Boiling Point | 563.7ºC at 760 mmHg | |
| Molecular Formula | C21H32Cl2FN3O2 | Melting Point | 203-218ºC | |
| MSDS | Chinese USA | Flash Point | 294.7ºC | |
| Symbol |
GHS07 |
Signal Word | Warning | |
Use of Pipamperone DihydrochloridePipamperone (Floropipamide; McN-JR 3345) dihydrochloride is a high-affinity antagonist of 5-HT2A receptor (pKi=8.2) and D4 receptor (pKi=8.0) and a low-affinity antagonist of D2 receptor (pKi=6.7)[1]. |
| Name | pipamperone dihydrochloride |
|---|---|
| Synonym | More Synonyms |
| Description | Pipamperone (Floropipamide; McN-JR 3345) dihydrochloride is a high-affinity antagonist of 5-HT2A receptor (pKi=8.2) and D4 receptor (pKi=8.0) and a low-affinity antagonist of D2 receptor (pKi=6.7)[1]. |
|---|---|
| Related Catalog | |
| Target |
PAR2, PAR4[6] |
| References |
| Boiling Point | 563.7ºC at 760 mmHg |
|---|---|
| Melting Point | 203-218ºC |
| Molecular Formula | C21H32Cl2FN3O2 |
| Molecular Weight | 448.40 |
| Flash Point | 294.7ºC |
| Exact Mass | 447.18600 |
| PSA | 66.64000 |
| LogP | 4.77450 |
| Vapour Pressure | 9.88E-13mmHg at 25°C |
| Storage condition | 2-8°C |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
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The use of dried blood spots for quantification of 15 antipsychotics and 7 metabolites with ultra-high performance liquid chromatography - tandem mass spectrometry.
Drug Test. Anal. 7 , 502-11, (2015) Therapeutic drug monitoring of antipsychotics is important in optimizing individual therapy. In psychiatric populations, classical venous blood sampling is experienced as frightening. Interest in alte... |
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Determination of Common Antipsychotics in Quantisal-Collected Oral Fluid by UHPLC-MS/MS: Method Validation and Applicability for Therapeutic Drug Monitoring.
Ther. Drug Monit. 38 , 87-97, (2016) Oral fluid (OF) is an interesting alternative for conventional blood testing in therapeutic drug monitoring. OF can be used for screening but its value for quantification has to be established.To eval... |
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German insurer finds a third of people over 65 take five or more drugs a day.
BMJ 346 , f3905, (2013)
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| Pipamperone Dihydrochloride |
| Pipamperone dihydrochloride |
| PipamperoneDihydrochloride |