Dimethylacrylshikonin

Modify Date: 2024-01-02 21:31:46

Dimethylacrylshikonin structure	Common Name	Dimethylacrylshikonin
	CAS Number	24502-79-2	Molecular Weight	370.396
	Density	1.3±0.1 g/cm3	Boiling Point	653.2±55.0 °C at 760 mmHg
	Molecular Formula	C₂₁H₂₂O₆	Melting Point	103ºC
	MSDS	N/A	Flash Point	362.8±28.0 °C

Use of Dimethylacrylshikonin

β,β-Dimethylacrylshikonin is a naphthoquinone derivative isolated from Arnebia nobilis, promotes angiogenesis by inducing eNOS, VEGF and HIF-1α expression through the PI3K-dependent pathway. Arnebin 1 has anti-tumor activity[1].

Name	(β,β-DIMETHYLACRYL)SHIKONIN
Synonym	More Synonyms

Description	β,β-Dimethylacrylshikonin is a naphthoquinone derivative isolated from Arnebia nobilis, promotes angiogenesis by inducing eNOS, VEGF and HIF-1α expression through the PI3K-dependent pathway. Arnebin 1 has anti-tumor activity[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Others >> Others
References	[1]. Zeng Z, et al. Arnebin-1 promotes angiogenesis by inducing eNOS, VEGF and HIF-1α expression through the PI3K-dependent pathway. Int J Mol Med. 2015 Sep;36(3):685-97. [2]. Sidhu GS, et al. Arnebin-1 accelerates normal and hydrocortisone-induced impaired wound healing. J Invest Dermatol. 1999 Nov;113(5):773-81.

Description

Related Catalog

Research Areas >> Cancer

Signaling Pathways >> Others >> Others

References

[1]. Zeng Z, et al. Arnebin-1 promotes angiogenesis by inducing eNOS, VEGF and HIF-1α expression through the PI3K-dependent pathway. Int J Mol Med. 2015 Sep;36(3):685-97.

[2]. Sidhu GS, et al. Arnebin-1 accelerates normal and hydrocortisone-induced impaired wound healing. J Invest Dermatol. 1999 Nov;113(5):773-81.

Density	1.3±0.1 g/cm3
Boiling Point	653.2±55.0 °C at 760 mmHg
Melting Point	103ºC
Molecular Formula	C₂₁H₂₂O₆
Molecular Weight	370.396
Flash Point	362.8±28.0 °C
Exact Mass	370.141632
PSA	100.90000
LogP	4.45
Vapour Pressure	0.0±2.1 mmHg at 25°C
Index of Refraction	1.616

Dimethylacrylshikonin MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: EM9252400

CHEMICAL NAME :: 2-Butenoic acid, 3-methyl-, 1-(1,4-dihydro-5,8-dihydroxy-1,4-dioxo-2-naphthalenyl )-4-methyl- 3-pentenyl ester, (+)-

CAS REGISTRY NUMBER :: 24502-79-2

LAST UPDATED :: 198208

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C21-H22-O6

MOLECULAR WEIGHT :: 370.43

WISWESSER LINE NOTATION :: L66 BV EVJ CY2UY1&1&OV1UY1&1 GQ JQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 48 mg/kg

TOXIC EFFECTS :: Lungs, Thorax, or Respiration - dyspnea

REFERENCE :: CYLPDN Zhongguo Yaoli Xuebao. Acta Pharmacologica Sinica. Chinese Journal of Pharmacology. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.1- 1980- Volume(issue)/page/year: 1,60,1980

Safety Phrases	22-24/25
RTECS	EM9252400
HS Code	2916129000

HS Code	2916129000
Summary	2916129000 other esters of acrylic acid VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

(BETA,BETA-DIMETHYLACRYL)SHIKONIN

2-Butenoic acid, 3-methyl-, (1R)-1-(1,4-dihydro-5,8-dihydroxy-1,4-dioxo-2-naphthalenyl)-4-methyl-3-pentenyl ester

dmask

1,4-Naphthalenedione, 5,8-dihydroxy-2-[(1R,3E)-1-hydroxy-4,8-dimethyl-6-oxo-3,7-nonadien-1-yl]-

2-Butenoic acid, 3-methyl-, 1-(1,4-dihydro-5,8-dihydroxy-1,4-dioxo-2-naphthalenyl)-4-methyl-3-pentenyl ester, (R)-

(1R)-1-(5,8-Dihydroxy-1,4-dioxo-1,4-dihydro-2-naphthalenyl)-4-methyl-3-penten-1-yl 3-methyl-2-butenoate

2-Butenoic acid, 3-methyl-, (1R)-1-(1,4-dihydro-5,8-dihydroxy-1,4-dioxo-2-naphthalenyl)-4-methyl-3-penten-1-yl ester

Senecioylshikonin

Dimethylacrylshikonin

Isoarnebin I

b,b-Dimethylacrylshikonin

5,8-Dihydroxy-2-[(1R,3E)-1-hydroxy-4,8-dimethyl-6-oxo-3,7-nonadien-1-yl]-1,4-naphthoquinone

(β,β-DiMethylacryl)shikonin

Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: Dimethylacrylshikonin
Price: ￥1198.0/20mg
Purity: 98.0%
Stocking Period: 1 Day
Contact: Liu jia

DC Chemicals Limited
China
Product Name: β,β-Dimethylacrylshikonin
Price: $280.0/20mg
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: (beta,beta-Dimethylacryl)shikonin
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

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Dimethylacrylshikonin

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