DA-PROTAC

Modify Date: 2024-01-10 04:04:01

DA-PROTAC structure	Common Name	DA-PROTAC
	CAS Number	2488660-12-2	Molecular Weight	1010.96
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₄₆H₅₀BrF₂N₇O₈S₂	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of DA-PROTAC

DA-PROTAC is a potent PROTAC degrader of copper ion-transport proteins Atox1 and CCS. DA-PROTAC can bind both Atox1 and CCS proteins, and the complex can be bound to E3 ligase, leading to increased levels of ubiquitination of Atox1 and CCS and degradation of Atox1 and CCS proteins via the proteasome pathway. DA-PROTAC can be used for triple negative breast cancer research[1].

Name	DA-PROTAC

Description	DA-PROTAC is a potent PROTAC degrader of copper ion-transport proteins Atox1 and CCS. DA-PROTAC can bind both Atox1 and CCS proteins, and the complex can be bound to E3 ligase, leading to increased levels of ubiquitination of Atox1 and CCS and degradation of Atox1 and CCS proteins via the proteasome pathway. DA-PROTAC can be used for triple negative breast cancer research[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> PROTAC >> PROTAC Signaling Pathways >> PROTAC >> Ligand for E3 Ligase
Target	VHL
In Vitro	DA-PROTAC (0-1 μM, 24 h) can degrade Atox1 and CCS proteins rather than inhibit Atox1 and CCS activity[1]. DA-PROTAC (5 μM, 24 h) inhibits the proliferation, migration and invasion of triple negative breast cancer cells (MDA-MB-231)[1]. DA-PROTAC (10 μM, 48 h) inhibits the tumorigenic capacity of triple negative breast cancer cells (MDA-MB-231)[1]. The targeting module of DA-PROTAC is a small molecule VHL ligand1 combined with E3 ligase[1]. Western Blot Analysis[1] Cell Line: MDA-MB-231 cells Concentration: 100 nM ,200 nM ,500 nM , and 1000 nM Incubation Time: 24 h Result: Significantly reduced ATOX1 and CCS protein levels under 200nM, indicating that DA-PROTAC can degrade ATOX1 and CCS proteins.
References	[1]. Zhao Yicheng, et al. Small-molecule inhibitor for degrading copper ion transporter Atox1 and CCS and application thereof. CN111471054A.

Molecular Formula	C₄₆H₅₀BrF₂N₇O₈S₂
Molecular Weight	1010.96

Shanghai Nianxing Industrial Co., Ltd
China
Product Name: DA-PROTAC
Price: ￥Inquiry/100mg ￥Inquiry/250mg ￥Inquiry/1g
Purity: 98.0%
Delivery: 10 Day
Contact: Huang
Email: sales@echemcloud.com

DC Chemicals Limited
China
Product Name: DA-PROTAC
Price: ￥Inquiry/100mg ￥Inquiry/250mg ￥Inquiry/1g
Purity: 98.0%
Delivery: 10 Day
Contact: Tony Cao
Email: sales@dcchemicals.com

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