RMS5

Modify Date: 2024-04-06 14:04:51

RMS5 structure	Common Name	RMS5
	CAS Number	2497686-68-5	Molecular Weight	598.75
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₃₅H₃₈N₂O₅S	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of RMS5

RMS5, a tetrandrine analogue, is a potent P-glycoprotein (P-gp) inhibitor. RMS5 has markedly antiproliferative and cytotoxic effects on cancer cells. RMS5 slightly diminishes the expression of the anti-apoptotic Bcl-2 family proteins Bcl-XL and Mcl-1. RMS3 causes PARP cleavage, a marker for cells undergoing apoptosis. RMS5 has strong anticancer property[1].

Name	RMS5

Description	RMS5, a tetrandrine analogue, is a potent P-glycoprotein (P-gp) inhibitor. RMS5 has markedly antiproliferative and cytotoxic effects on cancer cells. RMS5 slightly diminishes the expression of the anti-apoptotic Bcl-2 family proteins Bcl-XL and Mcl-1. RMS3 causes PARP cleavage, a marker for cells undergoing apoptosis. RMS5 has strong anticancer property[1].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer Signaling Pathways >> Membrane Transporter/Ion Channel >> P-glycoprotein
References	[1]. RamonaSchütz, et al. Synthesis, biological evaluation and toxicity of novel tetrandrine analogues. Eur J Med Chem. 2020 Dec 1;207:112810.

Molecular Formula	C₃₅H₃₈N₂O₅S
Molecular Weight	598.75

RMS5

Use of RMS5

Names

RMS5 Biological Activity

Chemical & Physical Properties