p-chlorophenylacetyl chloride

Modify Date: 2024-01-02 18:22:05

p-chlorophenylacetyl chloride Structure
p-chlorophenylacetyl chloride structure
Common Name p-chlorophenylacetyl chloride
CAS Number 25026-34-0 Molecular Weight 189.039
Density 1.3±0.1 g/cm3 Boiling Point 254.7±23.0 °C at 760 mmHg
Molecular Formula C8H6Cl2O Melting Point N/A
MSDS Chinese USA Flash Point 103.0±22.9 °C
Symbol GHS05 GHS07
GHS05, GHS07
Signal Word Danger

 Names

Name 2-(4-chlorophenyl)acetyl chloride
Synonym More Synonyms

 Chemical & Physical Properties

Density 1.3±0.1 g/cm3
Boiling Point 254.7±23.0 °C at 760 mmHg
Molecular Formula C8H6Cl2O
Molecular Weight 189.039
Flash Point 103.0±22.9 °C
Exact Mass 187.979568
PSA 17.07000
LogP 2.83
Vapour Pressure 0.0±0.5 mmHg at 25°C
Index of Refraction 1.552

 MSDS

Name: 4-Chlorobenzeneacetyl chloride 98% Material Safety Data Sheet
Synonym: 4-Chlorophenylacetyl chloride
CAS: 25026-34-0
Section 1 - Chemical Product MSDS Name:4-Chlorobenzeneacetyl chloride 98% Material Safety Data Sheet
Synonym:4-Chlorophenylacetyl chloride

Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS
CAS# Chemical Name content EINECS#
25026-34-0 4-Chlorobenzeneacetyl chloride, 98% 98 246-571-1
Hazard Symbols: C
Risk Phrases: 34

Section 3 - HAZARDS IDENTIFICATION
EMERGENCY OVERVIEW
Causes burns.Corrosive.
Potential Health Effects
Eye:
Causes eye burns. May cause chemical conjunctivitis and corneal damage.
Skin:
Causes skin burns. May cause skin rash (in milder cases), and cold and clammy skin with cyanosis or pale color.
Ingestion:
May cause severe and permanent damage to the digestive tract. Causes gastrointestinal tract burns. May cause perforation of the digestive tract. May cause systemic effects.
Inhalation:
May cause severe irritation of the respiratory tract with sore throat, coughing, shortness of breath and delayed lung edema. Causes chemical burns to the respiratory tract. Aspiration may lead to pulmonary edema. May cause systemic effects.
Chronic:
Effects may be delayed.

Section 4 - FIRST AID MEASURES
Eyes: Get medical aid immediately. Do NOT allow victim to rub eyes or keep eyes closed. Extensive irrigation with water is required (at least 30 minutes).
Skin:
Get medical aid immediately. Immediately flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse. Destroy contaminated shoes.
Ingestion:
Do not induce vomiting. If victim is conscious and alert, give 2-4 cupfuls of milk or water. Never give anything by mouth to an unconscious person. Get medical aid immediately.
Inhalation:
Get medical aid immediately. Remove from exposure and move to fresh air immediately. If breathing is difficult, give oxygen. Do NOT use mouth-to-mouth resuscitation. If breathing has ceased apply artificial respiration using oxygen and a suitable mechanical device such as a bag and a mask.
Notes to Physician:

Section 5 - FIRE FIGHTING MEASURES
General Information:
As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Vapors may be heavier than air. They can spread along the ground and collect in low or confined areas.
Extinguishing Media:
In case of fire, use water, dry chemical, chemical foam, or alcohol-resistant foam. Use agent most appropriate to extinguish fire.

Section 6 - ACCIDENTAL RELEASE MEASURES
General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks:
Absorb spill with inert material (e.g. vermiculite, sand or earth), then place in suitable container. Clean up spills immediately, observing precautions in the Protective Equipment section. Provide ventilation.

Section 7 - HANDLING and STORAGE
Handling:
Remove contaminated clothing and wash before reuse. Use only in a well-ventilated area. Do not breathe dust, vapor, mist, or gas. Do not get in eyes, on skin, or on clothing. Keep container tightly closed. Do not ingest or inhale. Discard contaminated shoes.
Storage:
Keep container closed when not in use. Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances. Corrosives area.

Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION
Engineering Controls:
Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Use adequate ventilation to keep airborne concentrations low.
Exposure Limits CAS# 25026-34-0: Personal Protective Equipment Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166.
Skin:
Wear appropriate protective gloves to prevent skin exposure.
Clothing:
Wear appropriate protective clothing to prevent skin exposure.
Respirators:
A respiratory protection program that meets OSHA's 29 CFR 1910.134 and ANSI Z88.2 requirements or European Standard EN 149 must be followed whenever workplace conditions warrant respirator use.

Section 9 - PHYSICAL AND CHEMICAL PROPERTIES

Physical State: Liquid
Color: red-pink
Odor: None reported.
pH: Not available.
Vapor Pressure: Not available.
Viscosity: Not available.
Boiling Point: Not available.
Freezing/Melting Point: Not available.
Autoignition Temperature: Not applicable.
Flash Point: Not applicable.
Explosion Limits, lower: Not available.
Explosion Limits, upper: Not available.
Decomposition Temperature:
Solubility in water:
Specific Gravity/Density:
Molecular Formula: C8H6Cl2O
Molecular Weight: 189.04

Section 10 - STABILITY AND REACTIVITY
Chemical Stability:
Stable under normal temperatures and pressures.
Conditions to Avoid:
Incompatible materials, excess heat.
Incompatibilities with Other Materials:
Strong oxidizing agents.
Hazardous Decomposition Products:
Hydrogen chloride, carbon monoxide, irritating and toxic fumes and gases, carbon dioxide.
Hazardous Polymerization: Has not been reported.

Section 11 - TOXICOLOGICAL INFORMATION
RTECS#:
CAS# 25026-34-0 unlisted.
LD50/LC50:
Not available.
Carcinogenicity:
4-Chlorobenzeneacetyl chloride, 98% - Not listed by ACGIH, IARC, or NTP.

Section 12 - ECOLOGICAL INFORMATION


Section 13 - DISPOSAL CONSIDERATIONS
Dispose of in a manner consistent with federal, state, and local regulations.

Section 14 - TRANSPORT INFORMATION

IATA
Shipping Name: CORROSIVE LIQUID, ACIDIC, ORGANIC, N.O.S.
Hazard Class: 8
UN Number: 3265
Packing Group: II
IMO
Shipping Name: CORROSIVE LIQUID, ACIDIC, ORGANIC, N.O.S.
Hazard Class: 8
UN Number: 3265
Packing Group: II
RID/ADR
Shipping Name: CORROSIVE LIQUID, ACIDIC, ORGANIC, N.O.S.
Hazard Class: 8
UN Number: 3265
Packing group: II

Section 15 - REGULATORY INFORMATION

European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols: C
Risk Phrases:
R 34 Causes burns.
Safety Phrases:
S 24/25 Avoid contact with skin and eyes.
WGK (Water Danger/Protection)
CAS# 25026-34-0: No information available.
Canada
None of the chemicals in this product are listed on the DSL/NDSL list.
CAS# 25026-34-0 is not listed on Canada's Ingredient Disclosure List.
US FEDERAL
TSCA
CAS# 25026-34-0 is not listed on the TSCA inventory.
It is for research and development use only.


SECTION 16 - ADDITIONAL INFORMATION
N/A

 Safety Information

Symbol GHS05 GHS07
GHS05, GHS07
Signal Word Danger
Hazard Statements H302-H314-H317
Precautionary Statements P280-P305 + P351 + P338-P310
Personal Protective Equipment Faceshields;full-face respirator (US);Gloves;Goggles;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
Hazard Codes C:Corrosive;
Risk Phrases R34
Safety Phrases S26-S36/37/39-S45-S24/25
RIDADR UN 3265 8/PG 2
WGK Germany 3
Packaging Group II
Hazard Class 8
HS Code 2916399090

 Synthetic Route

~97%

p-chlorophenylacetyl chloride Structure

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CAS#:25026-34-0

Literature: Chatterjee, Arnab K.; Liu, Hong; Tully, David C.; Guo, Jianhua; Epple, Robert; Russo, Ross; Williams, Jennifer; Roberts, Michael; Tuntland, Tove; Chang, Jonathan; Gordon, Perry; Hollenbeck, Thomas; Tumanut, Christine; Li, Jun; Harris, Jennifer L. Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 10 p. 2899 - 2903

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p-chlorophenylacetyl chloride Structure

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CAS#:25026-34-0

Literature: Bioorganic and Medicinal Chemistry Letters, , vol. 10, # 15 p. 1723 - 1727

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p-chlorophenylacetyl chloride Structure

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CAS#:25026-34-0

Literature: Bioorganic and Medicinal Chemistry Letters, , vol. 10, # 15 p. 1723 - 1727

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p-chlorophenylacetyl chloride Structure

p-chlorophenyla...

CAS#:25026-34-0

Literature: Bioorganic and Medicinal Chemistry Letters, , vol. 10, # 15 p. 1723 - 1727

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p-chlorophenylacetyl chloride Structure

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CAS#:25026-34-0

Literature: US4724263 A1, ;

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p-chlorophenylacetyl chloride Structure

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CAS#:25026-34-0

Literature: Scientia Pharmaceutica, , vol. 69, # 4 p. 329 - 350

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p-chlorophenylacetyl chloride Structure

p-chlorophenyla...

CAS#:25026-34-0

Literature: Scientia Pharmaceutica, , vol. 69, # 4 p. 329 - 350

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p-chlorophenylacetyl chloride Structure

p-chlorophenyla...

CAS#:25026-34-0

Literature: Scientia Pharmaceutica, , vol. 69, # 4 p. 329 - 350

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p-chlorophenylacetyl chloride Structure

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CAS#:25026-34-0

Literature: Biochemische Zeitschrift, , vol. 27, p. 102

 Customs

HS Code 2916399090
Summary 2916399090 other aromatic monocarboxylic acids, their anhydrides, halides, peroxides, peroxyacids and their derivatives VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

 Synonyms

4-chlorophenylacetic acid chloride
parachlorophenyl acetyl chloride
Benzeneacetyl chloride, 4-chloro-
4-Chlorobenzeneacetyl chloride
MFCD00037111
EINECS 246-571-1
p-chlorophenylacetyl chloride
4-Chlorophenylacetyl chloride
(4-Chlorophenyl)acetyl chloride
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