Solabegron
Modify Date: 2024-01-09 18:34:50
Solabegron structure
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Common Name | Solabegron | ||
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| CAS Number | 252920-94-8 | Molecular Weight | 410.89 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C23H23ClN2O3 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of SolabegronSolabegron (GW 427353) is a selective β3-adrenergic receptor agonist, stimulating cAMP accumulation in Chinese hamster ovary cells expressing the human β3-AR, with an EC50 value of 22 nM[1]. Solabegron (GW 427353) is being developed for the treatment of overactive bladder and irritable bowel syndrome[1]. |
| Name | [1,1'-Biphenyl]-3-carboxylicacid,3'-[[2-[[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl]aMino]ethyl]aMino]- |
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| Description | Solabegron (GW 427353) is a selective β3-adrenergic receptor agonist, stimulating cAMP accumulation in Chinese hamster ovary cells expressing the human β3-AR, with an EC50 value of 22 nM[1]. Solabegron (GW 427353) is being developed for the treatment of overactive bladder and irritable bowel syndrome[1]. |
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| Related Catalog | |
| Target |
EC50: 22 nM (β3-AR in cells)[1]. |
| In Vivo | Solabegron (GW427353) at 3 mg/kg i.v. evokes an increase in micturition volume threshold that prevented the acetic acid-evoked decreases in dogs. The low dose (1 mg/kg) shows no significant activity[1]. Animal Model: Adult female beagle dogs (6-10 kg)[1]. Dosage: 1, 3 mg/kg. Administration: I.V. once. Result: Dosage of 3 mg/kg evoked an increase in micturition volume threshold. |
| References |
| Molecular Formula | C23H23ClN2O3 |
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| Molecular Weight | 410.89 |
| Storage condition | 2-8℃ |