(S)-ATPO

Modify Date: 2024-01-06 20:26:19

(S)-ATPO structure	Common Name	(S)-ATPO
	CAS Number	252930-37-3	Molecular Weight	322.25
	Density	N/A	Boiling Point	569.2±60.0 °C
	Molecular Formula	C₁₁H₁₉N₂O₇P	Melting Point	N/A
	MSDS	Chinese USA	Flash Point	N/A

Use of (S)-ATPO

(S)-ATPO is the (S)-enantiomer of ATPO, which is a competitive antagonist at GluR1-4 (AMPA-preferring) receptors[1].

Name	2-amino-3-[5-tert-butyl-3-(phosphonomethoxy)-1,2-oxazol-4-yl]propanoic acid
Synonym	More Synonyms

Description	(S)-ATPO is the (S)-enantiomer of ATPO, which is a competitive antagonist at GluR1-4 (AMPA-preferring) receptors[1].
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Neurological Disease
In Vitro	ATPO is a competitive antagonist at GluR1-4 (AMPA-preferring) receptors[1].
References	[1]. Hogner A, et al. Competitive antagonism of AMPA receptors by ligands of different classes: crystal structure of ATPO bound to the GluR2 ligand-binding core, in comparison with DNQX. J Med Chem. 2003;46(2):214-221.

Boiling Point	569.2±60.0 °C
Molecular Formula	C₁₁H₁₉N₂O₇P
Molecular Weight	322.25
Exact Mass	322.09300
PSA	165.92000
LogP	1.14080
Storage condition	2-8°C

(S)-ATPO MSDS(Chinese)

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
RIDADR	NONH for all modes of transport

Synthesis and pharmacology of highly selective carboxy and phosphono isoxazole amino acid AMPA receptor antagonists.

J. Med. Chem. 39 , 1682-1691, (1996)

(RS)-2-Amino-3-(3-hydroxy-5-methyl-4-isoxazolyl)propionic acid (AMPA, 5) and the selective AMPA receptor antagonist (RS)-2-amino-3-[3-(carboxymethoxy)-5-methyl-4-isoxazolyl]propionic acid (AMOA, 7) ha...

Resolution, absolute stereochemistry, and enantiopharmacology of the GluR1-4 and GluR5 antagonist 2-amino-3-[5-tert-butyl-3-(phosphonomethoxy)-4-isoxazolyl]propionic acid.

Chirality 11 , 752-9, (1999)

The phosphono amino acid, (RS)-2-amino-3-[5-tert-butyl-3-(phosphonomethoxy)-4-isoxazolyl+ ++]propio nic acid (ATPO), is a structural hybrid between the NMDA antagonist (RS)-2-amino-7-phosphonoheptanoi...

Antagonist properties of a phosphono isoxazole amino acid at glutamate R1-4 (R,S)-2-amino-3-(3-hydroxy-5-methyl-4-isoxazolyl)propionic acid receptor subtypes.

Mol. Pharmacol. 53 , 590-6, (1998)

The activity of the (R, S)-2-amino-3-(3-hydroxy-5-methyl-4-isoxazolyl)propionic acid (AMPA) receptor antagonist, (R,S) -2-amino-3-[5-tert-butyl-3-(phosphonomethoxy)-4-isoxazolyl] propionic acid (ATPO)...

(S)-2-amino-3-[5-tertbutyl-3-(phosphono-methoxy)-4-isoxazolyl]propionic acid

HMS3260C06

ATPO

(R,S)-2-Amino-3-[5-tert-butyl-3-(phosphonomethoxy)-4-isoxazolyl]propionic acid