L-778123 (hydrochloride)
Modify Date: 2024-01-08 09:25:17
L-778123 (hydrochloride) structure
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Common Name | L-778123 (hydrochloride) | ||
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| CAS Number | 253863-00-2 | Molecular Weight | 442.341 | |
| Density | N/A | Boiling Point | 698.9ºC at 760 mmHg | |
| Molecular Formula | C22H21Cl2N5O | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 376.5ºC | |
Use of L-778123 (hydrochloride)L-778123 hydrochloride is an inhibitor of FPTase and GGPTase-I with IC50 of 2 nM and 98 nM in enzyme inhibition determination.IC50 value: 2 nM [1]Target: FPTasein vitro: L-778123 can completely inhibit Ki-Ras prenylation. [1] L-778123 as a farnesyltransferase inhibitor can have a good cytotoxic activity as a classic anti-cancer agent. [2]in vivo: In the dog model, L-778123 inhibits HDJ2 prenylation and produces measurable, albeit slight (5%), levels of unprenylatedRap1A in PBMCs. [1] |
| Name | 4-[[5-[[4-(3-chlorophenyl)-3-oxopiperazin-1-yl]methyl]imidazol-1-yl]methyl]benzonitrile,hydrochloride |
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| Synonym | More Synonyms |
| Description | L-778123 hydrochloride is an inhibitor of FPTase and GGPTase-I with IC50 of 2 nM and 98 nM in enzyme inhibition determination.IC50 value: 2 nM [1]Target: FPTasein vitro: L-778123 can completely inhibit Ki-Ras prenylation. [1] L-778123 as a farnesyltransferase inhibitor can have a good cytotoxic activity as a classic anti-cancer agent. [2]in vivo: In the dog model, L-778123 inhibits HDJ2 prenylation and produces measurable, albeit slight (5%), levels of unprenylatedRap1A in PBMCs. [1] |
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| Related Catalog | |
| References |
| Boiling Point | 698.9ºC at 760 mmHg |
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| Molecular Formula | C22H21Cl2N5O |
| Molecular Weight | 442.341 |
| Flash Point | 376.5ºC |
| Exact Mass | 441.112305 |
| PSA | 65.16000 |
| LogP | 4.11018 |
| Vapour Pressure | 2.22E-19mmHg at 25°C |
| Storage condition | 2-8℃ |
| Benzonitrile, 4-[[5-[[4-(3-chlorophenyl)-3-oxo-1-piperazinyl]methyl]-1H-imidazol-1-yl]methyl]-, hydrochloride (1:1) |
| 4-((5-((4-(3-Chlorophenyl)-3-oxo-1-piperazinyl)methyl)-1H-imidazol-1-yl)methyl)benzonitrile hydrochloride |
| 4-[(5-{[4-(3-Chlorophenyl)-3-oxo-1-piperazinyl]methyl}-1H-imidazol-1-yl)methyl]benzonitrile hydrochloride (1:1) |
| Benzonitrile,4-((5-((4-(3-chlorophenyl)-3-oxo-1-piperazinyl)methyl)-1H-imidazol-1-yl)methyl)-,monohydrochloride |
| 4-[(5-{[4-(3-chlorophenyl)-3-oxopiperazin-1-yl]methyl}-1h-imidazol-1-yl)methyl]benzonitrile hydrochloride(1:1) |
| L 778123 |
| L-778123 |
| L-778123 HCl |
| L-778123 (hydrochloride) |